Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4687136..4687917 Replicon chromosome
Accession NZ_CP101372
Organism Salmonella enterica strain SC2016025

Toxin (Protein)


Gene name TacT2 Uniprot ID E8X9W8
Locus tag NMU31_RS23120 Protein ID WP_000626099.1
Coordinates 4687136..4687627 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID B5R979
Locus tag NMU31_RS23125 Protein ID WP_001110452.1
Coordinates 4687624..4687917 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NMU31_RS23085 (4683131) 4683131..4683706 + 576 WP_001188509.1 transcriptional regulator -
NMU31_RS23095 (4683977) 4683977..4684054 - 78 Protein_4523 helix-turn-helix domain-containing protein -
NMU31_RS23100 (4684145) 4684145..4684477 - 333 WP_001165471.1 MerR family transcriptional regulator -
NMU31_RS23105 (4684549) 4684549..4684926 + 378 WP_000916345.1 EthD family reductase -
NMU31_RS23110 (4685959) 4685959..4686033 + 75 Protein_4526 porin family protein -
NMU31_RS23115 (4686136) 4686136..4686888 + 753 WP_000842434.1 non-specific acid phosphatase -
NMU31_RS23120 (4687136) 4687136..4687627 - 492 WP_000626099.1 GNAT family N-acetyltransferase Toxin
NMU31_RS23125 (4687624) 4687624..4687917 - 294 WP_001110452.1 DUF1778 domain-containing protein Antitoxin
NMU31_RS23130 (4688234) 4688234..4688455 + 222 WP_001576552.1 hypothetical protein -
NMU31_RS23135 (4688720) 4688720..4689595 + 876 WP_000921674.1 AraC family transcriptional regulator -
NMU31_RS23140 (4689592) 4689592..4689879 + 288 WP_001269916.1 transcriptional regulator RtsB -
NMU31_RS23145 (4689902) 4689902..4690117 + 216 WP_001595136.1 hypothetical protein -
NMU31_RS23150 (4690125) 4690125..4690394 + 270 WP_010989096.1 hypothetical protein -
NMU31_RS23155 (4690688) 4690688..4691593 - 906 WP_001268200.1 YjiK family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(85-145)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17646.39 Da        Isoelectric Point: 6.8437

>T251963 WP_000626099.1 NZ_CP101372:c4687627-4687136 [Salmonella enterica]
MISTPEPLHAGHILTPFCCGVDSIDNWLEQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPVVVLGRLAVDKSLHGQGVARALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10977.61 Da        Isoelectric Point: 8.6141

>AT251963 WP_001110452.1 NZ_CP101372:c4687917-4687624 [Salmonella enterica]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLVRLDQTPSPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7AK7

Antitoxin

Source ID Structure
PDB 7AK7
AlphaFold DB A0A5I1DGA4

References