251951

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 1013998..1015621 Replicon chromosome
Accession NZ_CP101372
Organism Salmonella enterica strain SC2016025

Toxin (Protein)


Gene name hipA Uniprot ID H9TH67
Locus tag NMU31_RS04985 Protein ID WP_000088046.1
Coordinates 1013998..1015323 (-) Length 442 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A5Z6V2D1
Locus tag NMU31_RS04990 Protein ID WP_024136327.1
Coordinates 1015328..1015621 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NMU31_RS04955 (1009982) 1009982..1010839 - 858 WP_000784387.1 HNH endonuclease signature motif containing protein -
NMU31_RS04960 (1010855) 1010855..1011163 - 309 WP_001224687.1 hypothetical protein -
NMU31_RS04965 (1011712) 1011712..1012137 - 426 WP_001043843.1 hypothetical protein -
NMU31_RS04970 (1012391) 1012391..1013206 - 816 WP_053276223.1 HNH endonuclease signature motif containing protein -
NMU31_RS04975 (1013219) 1013219..1013629 - 411 WP_000985911.1 hypothetical protein -
NMU31_RS04980 (1013731) 1013731..1013937 - 207 WP_000134171.1 hypothetical protein -
NMU31_RS04985 (1013998) 1013998..1015323 - 1326 WP_000088046.1 type II toxin-antitoxin system HipA family toxin Toxin
NMU31_RS04990 (1015328) 1015328..1015621 - 294 WP_024136327.1 helix-turn-helix transcriptional regulator Antitoxin
NMU31_RS04995 (1016225) 1016225..1016617 - 393 WP_000341066.1 hypothetical protein -
NMU31_RS05000 (1016990) 1016990..1017331 + 342 WP_001151575.1 hypothetical protein -
NMU31_RS05005 (1017423) 1017423..1017614 + 192 WP_000398480.1 hypothetical protein -
NMU31_RS05010 (1017664) 1017664..1017945 + 282 WP_000077926.1 hypothetical protein -
NMU31_RS05015 (1018286) 1018286..1018417 - 132 WP_000374059.1 hypothetical protein -
NMU31_RS05020 (1018508) 1018508..1019749 - 1242 WP_001053338.1 VWA domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element mph(A) / mcr-1.1 / oqxB / oqxA / sul1 / sul3 / ant(3'')-Ia / cmlA1 / aadA2 / dfrA12 / floR / sul2 / aac(3)-IVa / fosA3 / blaCTX-M-14 - 967883..1274908 307025


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(9-108)

Antitoxin

Cro/C1-type helix-turn-helix domain

(21-69)


Sequences

Toxin        


Download         Length: 442 a.a.        Molecular weight: 50249.20 Da        Isoelectric Point: 6.1927

>T251951 WP_000088046.1 NZ_CP101372:c1015323-1013998 [Salmonella enterica]
MSRKQQRLVIWMNGIKVGYWEKSKGVDSLEYLPEWVADEQGRPLSLSLPFTPGNQVWRGNVVRDYFDNLLPDSEGIRRRL
AMRYKADSLEPFDLLTELGKDCVGAIQLLHDGDEPTDLYSVKYHPLTESEIAATLRNTTETLLPGRPEDNDDLRLSIAGA
QEKTALLWHEDRWCMPEGNTPTTHIFKLPLGLVGNMKADMSSSVENEWLCSVLLGQYGLPVARTQIAHFEDQKALVVERF
DRKWSGDGQWIIRLPQEDMCQALGVSPLRKYQADGGPGISEIMEVLSNSDRAERDKAQFFMTQIIFWMMAATDGHAKNFS
ISIGPQGRYHLTPNYDVLSAWPVIGHGNNQISWQKCKLAMAVRGSSNYYQIYRIQRRHWIRHGEITGLSKQQTEAMIEEI
IARTPGVIERVSGLLPDQFPQQLAESIFDGMRQQCRRLAEK

Download         Length: 1326 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10946.35 Da        Isoelectric Point: 10.0925

>AT251951 WP_024136327.1 NZ_CP101372:c1015621-1015328 [Salmonella enterica]
INNDYPLNTLNQLRPLLIGFRKANGLTQKDLSERLGVTQQTYSRLEANPASASIERLFKVFSILGVKISFSSATTSSERK
QTEEMLKSNSPARQEDW

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3T0VBU1

Antitoxin

Source ID Structure
AlphaFold DB A0A5Z6V2D1

References