Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 964069..964694 Replicon chromosome
Accession NZ_CP101372
Organism Salmonella enterica strain SC2016025

Toxin (Protein)


Gene name vapC Uniprot ID M7SD17
Locus tag NMU31_RS04735 Protein ID WP_000911336.1
Coordinates 964296..964694 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID M7S3S8
Locus tag NMU31_RS04730 Protein ID WP_000557549.1
Coordinates 964069..964296 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NMU31_RS04700 (959114) 959114..960631 + 1518 WP_000003339.1 lysine--tRNA ligase -
NMU31_RS04705 (960707) 960707..961252 - 546 WP_000133994.1 isopentenyl-diphosphate Delta-isomerase -
NMU31_RS04710 (961517) 961517..962275 + 759 WP_000244329.1 amidase activator ActS -
NMU31_RS04720 (962560) 962560..963366 - 807 WP_010989071.1 DUF1460 domain-containing protein -
NMU31_RS04725 (963641) 963641..963892 - 252 WP_001540858.1 hypothetical protein -
NMU31_RS04730 (964069) 964069..964296 + 228 WP_000557549.1 toxin-antitoxin system antitoxin VapB Antitoxin
NMU31_RS04735 (964296) 964296..964694 + 399 WP_000911336.1 tRNA(fMet)-specific endonuclease VapC Toxin
NMU31_RS04740 (965500) 965500..966036 + 537 WP_001038506.1 STM3031 family outer membrane protein -
NMU31_RS04745 (966083) 966083..966715 + 633 WP_000835265.1 YfdX family protein -
NMU31_RS04750 (967434) 967434..968018 + 585 WP_001244638.1 fimbrial protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-123)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14938.30 Da        Isoelectric Point: 7.2155

>T251950 WP_000911336.1 NZ_CP101372:964296-964694 [Salmonella enterica]
MLKFMLDTNTCIFTIKNKPEHIRERFNLNTSRMCISSITLMELIYGAEKSLAPERNLAVVEGFISRLEVLDYDTQAAIHT
GQIRAELARKGTPVGPYDQMIAGHAGSRGLVVVTNNLREFERIPGIRIEDWC

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8514.51 Da        Isoelectric Point: 5.0210

>AT251950 WP_000557549.1 NZ_CP101372:964069-964296 [Salmonella enterica]
MHTTLFFSNRTQAVRLPKSISFPEDVKHVEIIAVGRSRIITPVGESWDSWFDGEGASTDFMSTREQPAVQEREGF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6IFC
PDB 6IFM

Antitoxin

Source ID Structure
PDB 6IFM
AlphaFold DB A0A3V2Y5V5

References