Detailed information of TA system TA025195

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): slvAT/RES(toxin)
• Location: 4591168..4592084
• Replicon: chromosome
• Accession: NC_015422
• Organism: Alicycliphilus denitrificans K601

Toxin (Protein)

• Gene name: slvT
• Uniprot ID: F4G8H2
• Locus tag: ALIDE2_RS21765
• Protein ID: WP_013520794.1
• Coordinates: 4591168..4591716 (-)
• Length: 183 a.a.

Antitoxin (Protein)

• Gene name: slvA
• Uniprot ID: F4G8H3
• Locus tag: ALIDE2_RS21770
• Protein ID: WP_013723152.1
• Coordinates: 4591713..4592084 (-)
• Length: 124 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ALIDE2_RS21735	4586264..4587064	-	801	WP_013520762.1	indole-3-glycerol phosphate synthase TrpC	-
ALIDE2_RS25320	4587071..4587223	-	153	WP_013520763.1	hypothetical protein	-
ALIDE2_RS21740	4587220..4588251	-	1032	WP_013520764.1	anthranilate phosphoribosyltransferase	-
ALIDE2_RS21745	4588251..4588823	-	573	WP_013723150.1	aminodeoxychorismate/anthranilate synthase component II	-
ALIDE2_RS21760	4590854..4591186	+	333	WP_148262987.1	hypothetical protein	-
ALIDE2_RS21765	4591168..4591716	-	549	WP_013520794.1	RES family NAD+ phosphorylase	Toxin
ALIDE2_RS21770	4591713..4592084	-	372	WP_013723152.1	MbcA/ParS/Xre antitoxin family protein	Antitoxin
ALIDE2_RS21775	4592399..4592740	-	342	WP_013723153.1	chorismate mutase	-
ALIDE2_RS21780	4592737..4594236	-	1500	WP_013723154.1	anthranilate synthase component I	-
ALIDE2_RS21785	4594579..4596339	+	1761	WP_013723155.1	MCP four helix bundle domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (15-168)

Antitoxin

• Antitoxin Xre/MbcA/ParS-like, toxin-binding domain (71-120)

Sequences

Toxin

Protein

• Length: 183 a.a.
• Molecular weight: 20105.95 Da
• Isoelectric Point: 4.7789

>T25195 WP_013520794.1 NC_015422:c4591716-4591168 [Alicycliphilus denitrificans K601]
MIPVAILGEGKAEAFYRIISPAYAGMPLSGMGAARQGGRFNRPGQEALYLAMDEATALAEYKQDNPWLRPGTICTFFVKG
LRVADFSAGFDPQKWPPLWADFAVDWRAEWFGKSVEPPTWYMSEDVIAEGLDGILFPSQARPDGINLVVYRSSARPADQL
RVYDPDGVLPKIAPFAGHPWTP

Nucleotide

• Length: 549 bp

>T25195 NC_015422:c4591716-4591168 [Alicycliphilus denitrificans K601]
ATGATTCCAGTCGCGATCCTCGGCGAGGGCAAGGCCGAGGCTTTCTACCGCATCATCTCACCCGCTTATGCTGGCATGCC
GCTGTCCGGTATGGGGGCTGCGCGCCAGGGCGGTCGCTTCAATCGGCCCGGCCAGGAAGCCCTCTATCTGGCGATGGATG
AAGCCACTGCATTGGCGGAATACAAGCAGGACAACCCGTGGCTGCGTCCGGGCACGATCTGTACGTTCTTTGTCAAAGGG
CTGCGGGTGGCGGACTTCAGTGCGGGCTTCGATCCACAGAAGTGGCCGCCATTGTGGGCTGATTTCGCGGTGGACTGGCG
AGCGGAGTGGTTCGGTAAATCGGTTGAACCGCCGACTTGGTATATGTCCGAGGATGTGATTGCTGAGGGACTTGATGGAA
TCCTGTTCCCCTCGCAGGCACGGCCTGACGGCATCAATCTGGTGGTCTACCGGAGTTCTGCAAGGCCCGCGGACCAGTTG
CGCGTGTACGACCCCGATGGCGTTCTGCCGAAGATCGCTCCCTTCGCTGGTCACCCATGGACACCCTGA

Antitoxin

Protein

• Length: 124 a.a.
• Molecular weight: 13498.41 Da
• Isoelectric Point: 5.7134

>AT25195 WP_013723152.1 NC_015422:c4592084-4591713 [Alicycliphilus denitrificans K601]
MSAVLQQPFVEQFREPGTPYLSPALLGDFLGFQIQELAERAHVHRNTPTARPQAPQLQKYLQDMVRVLAVATEMTGDEKR
AAFLVRNEPLRAFGYKTADALVQEGRVDAVIAYLESLAGGAAG

Nucleotide

• Length: 372 bp

>AT25195 NC_015422:c4592084-4591713 [Alicycliphilus denitrificans K601]
ATGAGCGCCGTGCTGCAACAGCCTTTTGTCGAGCAATTCCGCGAGCCGGGTACGCCGTATCTGTCTCCGGCCCTGCTCGG
GGATTTCCTCGGTTTCCAGATTCAGGAGTTGGCGGAGCGCGCCCACGTGCACCGCAATACCCCGACCGCCAGGCCCCAGG
CGCCACAACTGCAAAAGTACCTTCAGGACATGGTGCGGGTACTTGCTGTGGCTACCGAGATGACCGGCGACGAAAAGCGT
GCGGCCTTTCTTGTGCGCAATGAACCGCTGCGCGCCTTCGGCTACAAGACCGCCGATGCCTTGGTTCAGGAGGGGCGGGT
CGATGCGGTCATTGCCTATCTGGAGTCGCTTGCAGGCGGTGCTGCTGGATGA

Structures

Toxin

• AlphaFold DB: F4G8H2

Antitoxin

• AlphaFold DB: F4G8H3