Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 207596..208356 Replicon chromosome
Accession NZ_CP101372
Organism Salmonella enterica strain SC2016025

Toxin (Protein)


Gene name tacT Uniprot ID Q57IH1
Locus tag NMU31_RS00975 Protein ID WP_000533909.1
Coordinates 207871..208356 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID M7RHS4
Locus tag NMU31_RS00970 Protein ID WP_000965886.1
Coordinates 207596..207883 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NMU31_RS00945 (202891) 202891..203193 + 303 WP_000605590.1 YsaB family lipoprotein -
NMU31_RS00950 (203332) 203332..204243 + 912 WP_001168551.1 glycine--tRNA ligase subunit alpha -
NMU31_RS00955 (204253) 204253..206322 + 2070 WP_001291736.1 glycine--tRNA ligase subunit beta -
NMU31_RS00960 (206504) 206504..206779 + 276 Protein_190 IS3 family transposase -
NMU31_RS00965 (206951) 206951..207418 + 468 WP_000702452.1 GNAT family N-acetyltransferase -
NMU31_RS00970 (207596) 207596..207883 + 288 WP_000965886.1 DUF1778 domain-containing protein Antitoxin
NMU31_RS00975 (207871) 207871..208356 + 486 WP_000533909.1 GNAT family N-acetyltransferase Toxin
NMU31_RS00980 (208728) 208728..209267 - 540 WP_000047149.1 copper-binding periplasmic metallochaperone CueP -
NMU31_RS00985 (209441) 209441..209653 - 213 WP_000014594.1 RNA chaperone/antiterminator CspA -
NMU31_RS00990 (209942) 209942..210232 - 291 WP_000455790.1 HTH-type transcriptional regulator -
NMU31_RS00995 (210671) 210671..211381 + 711 WP_000190524.1 DUF3053 domain-containing protein -
NMU31_RS01000 (211431) 211431..212405 - 975 WP_000804674.1 glyoxylate/hydroxypyruvate reductase GhrB -
NMU31_RS01005 (212624) 212624..213286 - 663 WP_000747548.1 OmpA family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(31-152)

Antitoxin

Vibrio phage ICP1, Orf50

(5-94)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17703.41 Da        Isoelectric Point: 9.8719

>T251946 WP_000533909.1 NZ_CP101372:207871-208356 [Salmonella enterica]
VGRVTAPEPLSAFHQVAEFVSGEAVLDDWLKQKGLKNQALGAARTFVVCKKDTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDLSFHGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKSSQTQQRTLFLRLP
Q

Download         Length: 486 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10950.60 Da        Isoelectric Point: 4.6811

>AT251946 WP_000965886.1 NZ_CP101372:207596-207883 [Salmonella enterica]
MLYKGCLMKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILETACQAAEKVILDRRVFNFNDEQYEEFINLLDAPVADD
PVIEKLLARKPQWDV

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7F36
PDB 7AK8
PDB 5FVJ

Antitoxin

Source ID Structure
PDB 7AK8
AlphaFold DB A0A3V2JDX2

References