Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | TsxAB/MqsA(antitoxin) |
Location | 17211..17676 | Replicon | plasmid pSC2014238-mcr-33k |
Accession | NZ_CP101370 | ||
Organism | Salmonella enterica strain SC2014238 |
Toxin (Protein)
Gene name | TsxA | Uniprot ID | U9ZUY2 |
Locus tag | NMU30_RS24380 | Protein ID | WP_001230707.1 |
Coordinates | 17425..17676 (-) | Length | 84 a.a. |
Antitoxin (Protein)
Gene name | TsxB | Uniprot ID | M7CCF8 |
Locus tag | NMU30_RS24375 | Protein ID | WP_000801440.1 |
Coordinates | 17211..17438 (-) | Length | 76 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
NMU30_RS24335 (NMU30_24320) | 12441..12656 | - | 216 | WP_000760375.1 | EexN family lipoprotein | - |
NMU30_RS24340 (NMU30_24325) | 12653..12946 | - | 294 | WP_060598542.1 | sigma factor-like helix-turn-helix DNA-binding protein | - |
NMU30_RS24345 (NMU30_24330) | 13023..14252 | - | 1230 | WP_001329504.1 | DNA relaxase/nickase TaxC | - |
NMU30_RS24350 (NMU30_24335) | 14256..14759 | - | 504 | WP_000781813.1 | relaxosome-coupling protein TaxA | - |
NMU30_RS24355 (NMU30_24340) | 15120..15467 | - | 348 | WP_000681613.1 | type II toxin-antitoxin system HicB family antitoxin | - |
NMU30_RS24360 (NMU30_24345) | 15464..15712 | - | 249 | WP_000520549.1 | type II toxin-antitoxin system HicA family toxin | - |
NMU30_RS24365 (NMU30_24350) | 16017..16367 | - | 351 | WP_000854259.1 | hypothetical protein | - |
NMU30_RS24370 (NMU30_24355) | 16458..16757 | - | 300 | WP_000650309.1 | hypothetical protein | - |
NMU30_RS24375 (NMU30_24360) | 17211..17438 | - | 228 | WP_000801440.1 | hypothetical protein | Antitoxin |
NMU30_RS24380 (NMU30_24365) | 17425..17676 | - | 252 | WP_001230707.1 | hypothetical protein | Toxin |
NMU30_RS24385 (NMU30_24370) | 17673..18215 | - | 543 | WP_001083906.1 | hypothetical protein | - |
NMU30_RS24390 (NMU30_24375) | 18320..18835 | - | 516 | WP_001025395.1 | J domain-containing protein | - |
NMU30_RS24395 (NMU30_24380) | 20250..21116 | + | 867 | WP_001353743.1 | replication initiation protein | - |
NMU30_RS24400 (NMU30_24385) | 21129..21533 | + | 405 | WP_012421203.1 | hypothetical protein | - |
NMU30_RS24405 (NMU30_24390) | 21668..22195 | + | 528 | WP_000577043.1 | DUF2726 domain-containing protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Non-Mobilizable plasmid | mcr-1.1 | - | 1..33309 | 33309 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | U9ZUY2 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A5Y6U8W9 |