Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | hicAB/- |
Location | 15120..15712 | Replicon | plasmid pSC2014238-mcr-33k |
Accession | NZ_CP101370 | ||
Organism | Salmonella enterica strain SC2014238 |
Toxin (Protein)
Gene name | hicA | Uniprot ID | V0AGQ2 |
Locus tag | NMU30_RS24360 | Protein ID | WP_000520549.1 |
Coordinates | 15464..15712 (-) | Length | 83 a.a. |
Antitoxin (Protein)
Gene name | hicB | Uniprot ID | V0AWG0 |
Locus tag | NMU30_RS24355 | Protein ID | WP_000681613.1 |
Coordinates | 15120..15467 (-) | Length | 116 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
NMU30_RS24325 (NMU30_24310) | 11125..11451 | - | 327 | WP_000008647.1 | TrbC/VirB2 family protein | - |
NMU30_RS24330 (NMU30_24315) | 11465..12085 | - | 621 | WP_000157549.1 | lytic transglycosylase domain-containing protein | - |
NMU30_RS24335 (NMU30_24320) | 12441..12656 | - | 216 | WP_000760375.1 | EexN family lipoprotein | - |
NMU30_RS24340 (NMU30_24325) | 12653..12946 | - | 294 | WP_060598542.1 | sigma factor-like helix-turn-helix DNA-binding protein | - |
NMU30_RS24345 (NMU30_24330) | 13023..14252 | - | 1230 | WP_001329504.1 | DNA relaxase/nickase TaxC | - |
NMU30_RS24350 (NMU30_24335) | 14256..14759 | - | 504 | WP_000781813.1 | relaxosome-coupling protein TaxA | - |
NMU30_RS24355 (NMU30_24340) | 15120..15467 | - | 348 | WP_000681613.1 | type II toxin-antitoxin system HicB family antitoxin | Antitoxin |
NMU30_RS24360 (NMU30_24345) | 15464..15712 | - | 249 | WP_000520549.1 | type II toxin-antitoxin system HicA family toxin | Toxin |
NMU30_RS24365 (NMU30_24350) | 16017..16367 | - | 351 | WP_000854259.1 | hypothetical protein | - |
NMU30_RS24370 (NMU30_24355) | 16458..16757 | - | 300 | WP_000650309.1 | hypothetical protein | - |
NMU30_RS24375 (NMU30_24360) | 17211..17438 | - | 228 | WP_000801440.1 | hypothetical protein | - |
NMU30_RS24380 (NMU30_24365) | 17425..17676 | - | 252 | WP_001230707.1 | hypothetical protein | - |
NMU30_RS24385 (NMU30_24370) | 17673..18215 | - | 543 | WP_001083906.1 | hypothetical protein | - |
NMU30_RS24390 (NMU30_24375) | 18320..18835 | - | 516 | WP_001025395.1 | J domain-containing protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Non-Mobilizable plasmid | mcr-1.1 | - | 1..33309 | 33309 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A829CIX3 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A829CLC1 |