Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4282330..4282846 Replicon chromosome
Accession NZ_CP101369
Organism Salmonella enterica strain SC2014238

Toxin (Protein)


Gene name relE Uniprot ID A0A5I6CHB9
Locus tag NMU30_RS21270 Protein ID WP_000220581.1
Coordinates 4282330..4282614 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V7ISI8
Locus tag NMU30_RS21275 Protein ID WP_000212724.1
Coordinates 4282604..4282846 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NMU30_RS21255 (4277446) 4277446..4279098 + 1653 WP_070793923.1 alpha,alpha-phosphotrehalase -
NMU30_RS21260 (4279507) 4279507..4281645 + 2139 WP_000187818.1 anaerobic ribonucleoside-triphosphate reductase -
NMU30_RS21265 (4281862) 4281862..4282326 + 465 WP_001009175.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
NMU30_RS21270 (4282330) 4282330..4282614 - 285 WP_000220581.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NMU30_RS21275 (4282604) 4282604..4282846 - 243 WP_000212724.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
NMU30_RS21280 (4282924) 4282924..4284837 - 1914 WP_023216476.1 BglG family transcription antiterminator -
NMU30_RS21285 (4284854) 4284854..4285594 - 741 WP_000779254.1 KDGP aldolase family protein -
NMU30_RS21290 (4285591) 4285591..4286709 - 1119 WP_023216475.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
NMU30_RS21295 (4286693) 4286693..4287826 - 1134 WP_023216474.1 amidohydrolase/deacetylase family metallohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10868.70 Da        Isoelectric Point: 10.0482

>T251937 WP_000220581.1 NZ_CP101369:c4282614-4282330 [Salmonella enterica]
MTYELEFDPRALKEWHKLGDTVKAQLKKKLADVLLNPRIDSARLNGLPDCYKIKLKSSGYRLVYQVRDEVVIVFVVAVGK
REHSAVYHDANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.34 Da        Isoelectric Point: 5.0651

>AT251937 WP_000212724.1 NZ_CP101369:c4282846-4282604 [Salmonella enterica]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDSEDALIQTVRERLSSPQKGIKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5I6CHB9

Antitoxin

Source ID Structure
AlphaFold DB A0A5H5JRI5

References