Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 4241668..4242218 Replicon chromosome
Accession NZ_CP101369
Organism Salmonella enterica strain SC2014238

Toxin (Protein)


Gene name ccdB Uniprot ID M7RJ32
Locus tag NMU30_RS21065 Protein ID WP_001199743.1
Coordinates 4241668..4241976 (-) Length 103 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID V7ITQ8
Locus tag NMU30_RS21070 Protein ID WP_000016244.1
Coordinates 4241979..4242218 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NMU30_RS21045 (4238380) 4238380..4239159 - 780 WP_023216488.1 HNH endonuclease -
NMU30_RS21050 (4239320) 4239320..4239478 + 159 WP_023216487.1 hypothetical protein -
NMU30_RS21060 (4240986) 4240986..4241236 - 251 Protein_4059 Arm DNA-binding domain-containing protein -
NMU30_RS21065 (4241668) 4241668..4241976 - 309 WP_001199743.1 CcdB family protein Toxin
NMU30_RS21070 (4241979) 4241979..4242218 - 240 WP_000016244.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
NMU30_RS21075 (4242327) 4242327..4242575 - 249 WP_000254751.1 ribbon-helix-helix domain-containing protein -
NMU30_RS21080 (4242766) 4242766..4243197 - 432 Protein_4063 helix-turn-helix domain-containing protein -
NMU30_RS21090 (4243955) 4243955..4244974 + 1020 WP_000152563.1 NAD(P)-dependent alcohol dehydrogenase -
NMU30_RS21095 (4245002) 4245002..4245532 - 531 WP_000896756.1 gluconokinase -
NMU30_RS21100 (4245749) 4245749..4246780 + 1032 WP_023216483.1 L-idonate 5-dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside IScluster/Tn - - 4239694..4243152 3458


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-101)

Antitoxin

Post-segregation antitoxin CcdA

(9-79)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11845.67 Da        Isoelectric Point: 6.7228

>T251936 WP_001199743.1 NZ_CP101369:c4241976-4241668 [Salmonella enterica]
MQYMVYRNKGNSKAYPYLLDVQSDIIDELHTRMVIPLFPVSRLVNNPVKRLTPTLNVEGNDYLVMTHEMASIRLSQIGDE
VMDVRSHRQTIKNALDFIFDGF

Download         Length: 309 bp

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8709.86 Da        Isoelectric Point: 6.4633

>AT251936 WP_000016244.1 NZ_CP101369:c4242218-4241979 [Salmonella enterica]
MSGMSVRHKKTVSVTLEPALLQQARDAGINLSAVLTAALKEEISATGVERWKAENRAGLQELNRITDEHGLLSDDYRTF

Download         Length: 240 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6C6Z9V9

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5T4R8

References