Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3569387..3570007 Replicon chromosome
Accession NZ_CP101369
Organism Salmonella enterica strain SC2014238

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag NMU30_RS17990 Protein ID WP_001280991.1
Coordinates 3569789..3570007 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag NMU30_RS17985 Protein ID WP_000344807.1
Coordinates 3569387..3569761 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NMU30_RS17975 (3564526) 3564526..3565719 + 1194 WP_001039202.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
NMU30_RS17980 (3565742) 3565742..3568891 + 3150 WP_001132508.1 efflux RND transporter permease AcrB -
NMU30_RS17985 (3569387) 3569387..3569761 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
NMU30_RS17990 (3569789) 3569789..3570007 + 219 WP_001280991.1 HHA domain-containing protein Toxin
NMU30_RS17995 (3570186) 3570186..3570737 + 552 WP_001278793.1 maltose O-acetyltransferase -
NMU30_RS18000 (3570854) 3570854..3571324 + 471 WP_000136183.1 YlaC family protein -
NMU30_RS18005 (3571380) 3571380..3571520 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
NMU30_RS18010 (3571526) 3571526..3571786 - 261 WP_000801415.1 type B 50S ribosomal protein L31 -
NMU30_RS18015 (3572011) 3572011..3573561 + 1551 WP_000213145.1 EAL domain-containing protein -
NMU30_RS18025 (3573792) 3573792..3574181 + 390 WP_000961285.1 MGMT family protein -
NMU30_RS18030 (3574214) 3574214..3574783 - 570 WP_000779802.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T251933 WP_001280991.1 NZ_CP101369:3569789-3570007 [Salmonella enterica]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT251933 WP_000344807.1 NZ_CP101369:3569387-3569761 [Salmonella enterica]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References