251932

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 2475339..2475861 Replicon chromosome
Accession NZ_CP101369
Organism Salmonella enterica strain SC2014238

Toxin (Protein)


Gene name stbE Uniprot ID -
Locus tag NMU30_RS12395 Protein ID WP_023216422.1
Coordinates 2475577..2475861 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID V1H457
Locus tag NMU30_RS12390 Protein ID WP_000885424.1
Coordinates 2475339..2475587 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NMU30_RS12365 (2470384) 2470384..2471292 - 909 WP_001176641.1 LysR family transcriptional regulator -
NMU30_RS12370 (2472228) 2472228..2473008 + 781 Protein_2359 helix-turn-helix domain-containing protein -
NMU30_RS12375 (2473010) 2473010..2473423 - 414 Protein_2360 hypothetical protein -
NMU30_RS12380 (2474181) 2474181..2474570 + 390 WP_023216421.1 hypothetical protein -
NMU30_RS12385 (2474573) 2474573..2474926 + 354 WP_000418733.1 hypothetical protein -
NMU30_RS12390 (2475339) 2475339..2475587 + 249 WP_000885424.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
NMU30_RS12395 (2475577) 2475577..2475861 + 285 WP_023216422.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NMU30_RS12400 (2476032) 2476032..2476421 + 390 WP_000194089.1 RidA family protein -
NMU30_RS12405 (2476469) 2476469..2477548 - 1080 WP_023216423.1 S-adenosylmethionine:tRNA ribosyltransferase-isomerase -
NMU30_RS12410 (2477741) 2477741..2478229 - 489 WP_001293634.1 MarR family winged helix-turn-helix transcriptional regulator -
NMU30_RS12415 (2478274) 2478274..2479782 + 1509 WP_000199412.1 FAD-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2467512..2482639 15127


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-81)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11105.87 Da        Isoelectric Point: 10.5388

>T251932 WP_023216422.1 NZ_CP101369:2475577-2475861 [Salmonella enterica]
MTYKLAFNESALKEWKKLGHTIQEQFKKKLRERLENPWVPASQLHGRKDQYKIKLRGAGYRLVYSVEDEIITVTVIGVGK
RENDAVYKMTRHRS

Download         Length: 285 bp

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9090.32 Da        Isoelectric Point: 3.9820

>AT251932 WP_000885424.1 NZ_CP101369:2475339-2475587 [Salmonella enterica]
MAFQILTTTAASITELKRDPMGTFNAGDGAPVAILNRNEPAFYCVPPALYAHLMDILEDEELGRIIDERANERVIEVNID
DL

Download         Length: 249 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0WPN5

References