Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/PRK09812-MazE
Location 1995380..1995970 Replicon chromosome
Accession NZ_CP101369
Organism Salmonella enterica strain SC2014238

Toxin (Protein)


Gene name pemK Uniprot ID A0A8E7N510
Locus tag NMU30_RS09980 Protein ID WP_070793950.1
Coordinates 1995638..1995970 (+) Length 111 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID A0A5X3P062
Locus tag NMU30_RS09975 Protein ID WP_023216880.1
Coordinates 1995380..1995637 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NMU30_RS09960 (1992041) 1992041..1993996 - 1956 WP_070793949.1 hypothetical protein -
NMU30_RS09965 (1994356) 1994356..1994829 + 474 WP_023216882.1 hypothetical protein -
NMU30_RS09970 (1994826) 1994826..1995032 + 207 WP_024147225.1 helix-turn-helix transcriptional regulator -
NMU30_RS09975 (1995380) 1995380..1995637 + 258 WP_023216880.1 antitoxin PemI Antitoxin
NMU30_RS09980 (1995638) 1995638..1995970 + 333 WP_070793950.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
NMU30_RS09985 (1996817) 1996817..1997701 + 885 WP_023216878.1 integrase domain-containing protein -
NMU30_RS09990 (1998731) 1998731..1999993 - 1263 WP_023216875.1 integrase arm-type DNA-binding domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-108)

Antitoxin

Antitoxin PemI-like

(4-84)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 11765.58 Da        Isoelectric Point: 10.2965

>T251926 WP_070793950.1 NZ_CP101369:1995638-1995970 [Salmonella enterica]
MDRGEIWLVSLDPIAGHEQSGKRPVLIVSQASFNKLTRLPVIVPVTSGGNFARAAGFTVSLDGAGTKTTGVIRCDQPRTI
DMGARNGKRLERIPDAVVNEVLARLEAILS

Download         Length: 333 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9356.83 Da        Isoelectric Point: 4.4488

>AT251926 WP_023216880.1 NZ_CP101369:1995380-1995637 [Salmonella enterica]
MYTTRLKKVGGSVMLAVPPAVLKTLGLSTDSEVGMTIDNGCLIIEPQKRPRYSLEELLAQCDPHAEMSEEDREWIDAPAV
GKEIL

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A5X3P062

References