Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1016753..1017567 Replicon chromosome
Accession NZ_CP101369
Organism Salmonella enterica strain SC2014238

Toxin (Protein)


Gene name TacT3 Uniprot ID A0A8E7N5G9
Locus tag NMU30_RS05180 Protein ID WP_023216105.1
Coordinates 1016753..1017280 (-) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID M7S6I2
Locus tag NMU30_RS05185 Protein ID WP_000855694.1
Coordinates 1017277..1017567 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NMU30_RS05150 (1012954) 1012954..1013352 + 399 Protein_949 cytoplasmic protein -
NMU30_RS05155 (1013543) 1013543..1013782 + 240 Protein_950 hypothetical protein -
NMU30_RS05160 (1013939) 1013939..1014607 + 669 WP_023216104.1 hypothetical protein -
NMU30_RS05165 (1014634) 1014634..1015128 + 495 WP_000424946.1 hypothetical protein -
NMU30_RS05170 (1015373) 1015373..1016029 - 657 WP_017441135.1 protein-serine/threonine phosphatase -
NMU30_RS05175 (1016256) 1016256..1016680 + 425 Protein_954 transposase -
NMU30_RS05180 (1016753) 1016753..1017280 - 528 WP_023216105.1 GNAT family N-acetyltransferase Toxin
NMU30_RS05185 (1017277) 1017277..1017567 - 291 WP_000855694.1 DUF1778 domain-containing protein Antitoxin
NMU30_RS05190 (1017837) 1017837..1018037 - 201 Protein_957 transposase -
NMU30_RS05195 (1018441) 1018441..1018884 - 444 WP_000715096.1 SPI-1 type III secretion system invasion lipoprotein InvH -
NMU30_RS05200 (1019340) 1019340..1019990 + 651 WP_023166786.1 type III secretion system transcriptional activator InvF -
NMU30_RS05205 (1019987) 1019987..1021675 + 1689 WP_000848101.1 type III secretion system outer membrane ring protein InvG -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - invH / invF / invG / invE / invA / invB 1016456..1025303 8847
- inside IScluster/Tn - - 1016456..1018037 1581


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19066.94 Da        Isoelectric Point: 9.4012

>T251925 WP_023216105.1 NZ_CP101369:c1017280-1016753 [Salmonella enterica]
MMFTDWHEAAIGKIHNRMNFDCGDADLNQFLQRHARQNHEIGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Download         Length: 528 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10664.50 Da        Isoelectric Point: 6.3133

>AT251925 WP_000855694.1 NZ_CP101369:c1017567-1017277 [Salmonella enterica]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNVLPVAQKIVDAAERVYLTERDTQMIMEILDNPPAP
NEKLLAAAFALPDMKK

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A3V8SJE7

References