Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 852339..852999 Replicon chromosome
Accession NZ_CP101369
Organism Salmonella enterica strain SC2014238

Toxin (Protein)


Gene name cptA Uniprot ID Q57K70
Locus tag NMU30_RS04440 Protein ID WP_000244756.1
Coordinates 852586..852999 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S5MU13
Locus tag NMU30_RS04435 Protein ID WP_000351186.1
Coordinates 852339..852605 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NMU30_RS04415 (848268) 848268..849701 - 1434 WP_023216365.1 6-phospho-beta-glucosidase BglA -
NMU30_RS04420 (849859) 849859..850170 + 312 WP_023216364.1 N(4)-acetylcytidine aminohydrolase -
NMU30_RS04425 (850334) 850334..850993 + 660 WP_000250289.1 hemolysin III family protein -
NMU30_RS04430 (851109) 851109..852089 - 981 WP_000874170.1 tRNA-modifying protein YgfZ -
NMU30_RS04435 (852339) 852339..852605 + 267 WP_000351186.1 FAD assembly factor SdhE Antitoxin
NMU30_RS04440 (852586) 852586..852999 + 414 WP_000244756.1 protein YgfX Toxin
NMU30_RS04445 (853052) 853052..853573 - 522 WP_001055885.1 flavodoxin FldB -
NMU30_RS04450 (853686) 853686..854582 + 897 WP_000434303.1 site-specific tyrosine recombinase XerD -
NMU30_RS04455 (854606) 854606..855319 + 714 WP_000745614.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
NMU30_RS04460 (855325) 855325..857058 + 1734 WP_000813394.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16183.15 Da        Isoelectric Point: 10.7537

>T251924 WP_000244756.1 NZ_CP101369:852586-852999 [Salmonella enterica]
VVLWQSDLRVSWRAQWISLLIHGLVAAVILLMPWPLSYTPLWMILLSLVVFDCVRSQRRINTCQGEIKLLMDGRLRWQGQ
DWTLLRPPWLLKSGMVLRLRAESGRHQHLWLAADSMEEAEWRELRRILLQQPISGQH

Download         Length: 414 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10550.05 Da        Isoelectric Point: 6.0783

>AT251924 WP_000351186.1 NZ_CP101369:852339-852605 [Salmonella enterica]
MDIHNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFVRLLQSDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E9V5

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0YWH4

References