Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 225488..226248 Replicon chromosome
Accession NZ_CP101369
Organism Salmonella enterica strain SC2014238

Toxin (Protein)


Gene name tacT Uniprot ID A0A8E7JZU9
Locus tag NMU30_RS01355 Protein ID WP_023216228.1
Coordinates 225763..226248 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID Q8Z2B2
Locus tag NMU30_RS01350 Protein ID WP_000965889.1
Coordinates 225488..225775 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NMU30_RS01335 (221916) 221916..222344 + 429 Protein_204 IS3 family transposase -
NMU30_RS01340 (222540) 222540..223310 - 771 WP_000456879.1 DUF3800 domain-containing protein -
NMU30_RS01345 (224337) 224337..225365 + 1029 WP_023196719.1 HNH endonuclease signature motif containing protein -
NMU30_RS01350 (225488) 225488..225775 + 288 WP_000965889.1 DUF1778 domain-containing protein Antitoxin
NMU30_RS01355 (225763) 225763..226248 + 486 WP_023216228.1 GNAT family N-acetyltransferase Toxin
NMU30_RS01360 (226619) 226619..227158 - 540 WP_000047140.1 copper-binding periplasmic metallochaperone CueP -
NMU30_RS01365 (227331) 227331..227543 - 213 WP_000014594.1 RNA chaperone/antiterminator CspA -
NMU30_RS01370 (227831) 227831..228121 - 291 WP_000455790.1 HTH-type transcriptional regulator -
NMU30_RS01375 (228560) 228560..229270 + 711 WP_000190524.1 DUF3053 domain-containing protein -
NMU30_RS01380 (229320) 229320..230294 - 975 WP_023216229.1 glyoxylate/hydroxypyruvate reductase GhrB -
NMU30_RS01385 (230513) 230513..231175 - 663 WP_000747548.1 OmpA family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(31-152)

Antitoxin

Vibrio phage ICP1, Orf50

(13-89)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17685.37 Da        Isoelectric Point: 9.8719

>T251922 WP_023216228.1 NZ_CP101369:225763-226248 [Salmonella enterica]
VGRVTAPEPLSAFHQVAEFVSGEAVLDDWLKQKGLKNQALGAARTFVVCKKDTKQVAGFYSLATGSVNHTEATGNLRRNI
PDPIPVIILARLAVDLSFHGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKSSQTQQRTLFLRLP
Q

Download         Length: 486 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10964.59 Da        Isoelectric Point: 4.6811

>AT251922 WP_000965889.1 NZ_CP101369:225488-225775 [Salmonella enterica]
MLYKGCLMKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILETACRAAENVILDRRVFNFNDEQYEEFINLLDAPVADD
PVIEKLLARKPQWDV

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A752RW74

References