Detailed information of TA system TA025192

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /Acetyltransf_4(toxin)
• Location: 4021351..4022783
• Replicon: chromosome
• Accession: NC_015410
• Organism: Pseudomonas mendocina NK-01

Toxin (Protein)

• Gene name: -
• Uniprot ID: A0A550FMU2
• Locus tag: MDS_RS18600
• Protein ID: WP_013716747.1
• Coordinates: 4022214..4022783 (-)
• Length: 190 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: MDS_RS18595
• Protein ID: WP_013716746.1
• Coordinates: 4021351..4022208 (-)
• Length: 286 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MDS_RS18580	4018273..4019178	-	906	WP_013716743.1	hypothetical protein	-
MDS_RS18585	4019189..4019761	-	573	WP_013716744.1	LemA family protein	-
MDS_RS18590	4019951..4021288	+	1338	WP_013716745.1	peptidase	-
MDS_RS18595	4021351..4022208	-	858	WP_013716746.1	AraC family transcriptional regulator	Antitoxin
MDS_RS18600	4022214..4022783	-	570	WP_013716747.1	GNAT family N-acetyltransferase	Toxin
MDS_RS18605	4022986..4026474	+	3489	WP_013716748.1	hybrid sensor histidine kinase/response regulator	-
MDS_RS18610	4026530..4027339	-	810	WP_026042105.1	MerR family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• GNAT domain (14-146)

Antitoxin

• AraC-type arabinose-binding/dimerisation domain (17-145)

Sequences

Toxin

Protein

• Length: 190 a.a.
• Molecular weight: 21511.68 Da
• Isoelectric Point: 7.2799

>T25192 WP_013716747.1 NC_015410:c4022783-4022214 [Pseudomonas mendocina NK-01]
MFKPQLVTLQRGALRLEPLSDADIPALVALAEANREELLYMSGTQRLDWYRSALADLREQRALPFVIRLGDELVGTTRFA
DFMNTLPACEIGWTWLDRNQHGSGLNTTIKYLMLRHAFDNWGMVRVQLKTAASNQRSQRAIEKLGAVREGLLRNHRRLAD
GRLDDTVLYSITDLEWPALREAMEAGFVA

Nucleotide

• Length: 570 bp

>T25192 NC_015410:c4022783-4022214 [Pseudomonas mendocina NK-01]
ATGTTCAAGCCGCAGCTGGTGACTTTGCAACGTGGCGCTTTGCGCCTGGAACCGCTCTCCGATGCGGATATCCCGGCGTT
GGTAGCGTTGGCCGAGGCCAATCGCGAAGAGCTGCTGTACATGAGCGGTACCCAGCGGCTGGACTGGTACCGCAGCGCCC
TGGCCGATCTGCGCGAGCAGCGCGCACTGCCGTTCGTCATTCGCCTGGGTGACGAGTTGGTGGGCACCACCCGTTTCGCC
GATTTCATGAACACCCTGCCGGCCTGCGAAATCGGCTGGACCTGGCTCGACCGCAATCAGCATGGCAGCGGCCTGAACAC
CACCATCAAGTACCTGATGCTCAGGCACGCCTTCGACAACTGGGGCATGGTCCGTGTGCAGCTGAAAACCGCTGCCAGCA
ACCAGCGCTCGCAACGTGCCATCGAGAAACTGGGTGCTGTCCGTGAGGGATTGCTGCGCAACCATCGCCGGCTGGCCGAT
GGCCGTCTCGACGATACCGTGCTGTACAGCATCACCGATCTGGAGTGGCCGGCGCTGCGAGAGGCGATGGAGGCGGGCTT
CGTCGCCTGA

Antitoxin

Protein

• Length: 286 a.a.
• Molecular weight: 31737.14 Da
• Isoelectric Point: 9.0437

>AT25192 WP_013716746.1 NC_015410:c4022208-4021351 [Pseudomonas mendocina NK-01]
MQAREQTRFWQASALSGVELLQARYLEQRFAPHVHEGFVFTVIEHGAQRFHHRGSDHLAPQGSMVLINPDEVHTGSKAHE
DGWRYRGFYPGNDQVLGALQDLGLAKTGMPSFSFSVLHDPQLHSAFLQLHRLLDGGAEALQQQLAWREAILLLFQRHARL
AEPAAPGREPWAVACAKQMLADRLIEPPSLEELAAAVNLSPFHFARVFRRATGLPPHAWLKQRRLEQARALLKTGCTAVT
VATQLGFADQSHLSRQFKQVYGVSPGEYRSAVARIVAEGAPLGER

Nucleotide

• Length: 858 bp

>AT25192 NC_015410:c4022208-4021351 [Pseudomonas mendocina NK-01]
ATGCAAGCCCGCGAGCAGACCCGCTTCTGGCAGGCATCCGCGTTGAGCGGAGTCGAGCTGTTGCAGGCTCGCTACCTCGA
ACAACGCTTCGCGCCTCATGTCCATGAGGGCTTCGTCTTCACCGTGATCGAGCACGGTGCGCAGCGTTTTCACCACCGTG
GCAGCGACCACCTGGCGCCACAGGGCAGCATGGTGCTGATCAACCCGGACGAAGTGCACACCGGTTCCAAGGCGCACGAG
GATGGCTGGCGTTATCGCGGCTTCTATCCGGGTAATGATCAGGTGCTGGGGGCGCTGCAGGATCTGGGCCTGGCCAAGAC
GGGCATGCCGTCGTTTTCCTTCAGCGTGCTGCATGATCCGCAGTTGCACAGCGCCTTCCTGCAACTGCATCGCCTTCTCG
ACGGCGGCGCCGAAGCACTGCAGCAGCAACTGGCCTGGCGCGAGGCGATTCTGCTGCTGTTCCAGCGTCACGCCAGGCTT
GCCGAGCCAGCTGCGCCCGGACGTGAGCCCTGGGCCGTAGCCTGTGCCAAGCAGATGCTCGCCGACCGCCTGATCGAGCC
GCCGTCCCTCGAAGAGCTGGCGGCTGCGGTCAACCTTTCACCTTTCCACTTCGCCCGGGTGTTTCGCCGTGCGACCGGTC
TGCCGCCGCACGCATGGCTCAAACAGCGTCGTCTGGAACAGGCGCGGGCGTTGCTCAAGACTGGCTGCACGGCGGTCACC
GTGGCGACGCAGCTGGGTTTTGCCGACCAGAGCCACCTGTCACGACAGTTCAAGCAGGTCTATGGCGTCAGCCCTGGCGA
ATATCGTAGCGCCGTGGCACGGATTGTGGCTGAGGGCGCGCCTCTTGGCGAACGGTGA

Structures

Toxin

• AlphaFold DB: A0A550FMU2