Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4345655..4346436 Replicon chromosome
Accession NZ_CP101365
Organism Salmonella enterica strain SC2014107

Toxin (Protein)


Gene name TacT2 Uniprot ID B5R980
Locus tag NM059_RS21330 Protein ID WP_000626100.1
Coordinates 4345655..4346146 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID B5R979
Locus tag NM059_RS21335 Protein ID WP_001110452.1
Coordinates 4346143..4346436 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NM059_RS21295 (4341650) 4341650..4342225 + 576 WP_001188509.1 transcriptional regulator -
NM059_RS21305 (4342496) 4342496..4342573 - 78 Protein_4167 helix-turn-helix domain-containing protein -
NM059_RS21310 (4342664) 4342664..4342996 - 333 WP_001165472.1 MerR family transcriptional regulator -
NM059_RS21315 (4343068) 4343068..4343445 + 378 WP_000916345.1 EthD family reductase -
NM059_RS21320 (4344478) 4344478..4344552 + 75 Protein_4170 porin family protein -
NM059_RS21325 (4344655) 4344655..4345407 + 753 WP_000842427.1 non-specific acid phosphatase -
NM059_RS21330 (4345655) 4345655..4346146 - 492 WP_000626100.1 GNAT family N-acetyltransferase Toxin
NM059_RS21335 (4346143) 4346143..4346436 - 294 WP_001110452.1 DUF1778 domain-containing protein Antitoxin
NM059_RS21340 (4346753) 4346753..4346974 + 222 WP_001654251.1 hypothetical protein -
NM059_RS21345 (4347239) 4347239..4348114 + 876 WP_000921676.1 AraC family transcriptional regulator -
NM059_RS21350 (4348111) 4348111..4348398 + 288 WP_001541332.1 transcriptional regulator RtsB -
NM059_RS21355 (4348538) 4348538..4348912 + 375 WP_230320449.1 Ig-like domain-containing protein -
NM059_RS21360 (4349207) 4349207..4350112 - 906 WP_001268198.1 YjiK family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(85-145)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17645.45 Da        Isoelectric Point: 7.7297

>T251916 WP_000626100.1 NZ_CP101365:c4346146-4345655 [Salmonella enterica]
MISTPEPLHAGHILTPFCCGVDSIDNWLKQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPVVVLGRLAVDKSLHGQGVARALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10977.61 Da        Isoelectric Point: 8.6141

>AT251916 WP_001110452.1 NZ_CP101365:c4346436-4346143 [Salmonella enterica]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLVRLDQTPSPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A656IQ80

Antitoxin

Source ID Structure
PDB 7AK7
AlphaFold DB A0A5I1DGA4

References