Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4206606..4207122 Replicon chromosome
Accession NZ_CP101365
Organism Salmonella enterica strain SC2014107

Toxin (Protein)


Gene name relE Uniprot ID A0A3V5VNJ7
Locus tag NM059_RS20535 Protein ID WP_000220577.1
Coordinates 4206606..4206890 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V7ISI8
Locus tag NM059_RS20540 Protein ID WP_000212724.1
Coordinates 4206880..4207122 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NM059_RS20520 (4201722) 4201722..4203374 + 1653 WP_079798427.1 alpha,alpha-phosphotrehalase -
NM059_RS20525 (4203783) 4203783..4205921 + 2139 WP_000187821.1 anaerobic ribonucleoside-triphosphate reductase -
NM059_RS20530 (4206138) 4206138..4206602 + 465 WP_001009173.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
NM059_RS20535 (4206606) 4206606..4206890 - 285 WP_000220577.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NM059_RS20540 (4206880) 4206880..4207122 - 243 WP_000212724.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
NM059_RS20545 (4207200) 4207200..4209113 - 1914 WP_001212131.1 BglG family transcription antiterminator -
NM059_RS20550 (4209130) 4209130..4209870 - 741 WP_000779252.1 KDGP aldolase family protein -
NM059_RS20555 (4209867) 4209867..4210985 - 1119 WP_001139178.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
NM059_RS20560 (4210969) 4210969..4212102 - 1134 WP_000459930.1 amidohydrolase/deacetylase family metallohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10912.71 Da        Isoelectric Point: 9.8739

>T251915 WP_000220577.1 NZ_CP101365:c4206890-4206606 [Salmonella enterica]
MTYELEFDPRALKEWHKLGDTVKAQLKKKLADVLLNPRIDSARLNDLPDCYKIKLKSSGYRLVYQVRDDVVIVFVVAVGK
REHSAVYHDANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.34 Da        Isoelectric Point: 5.0651

>AT251915 WP_000212724.1 NZ_CP101365:c4207122-4206880 [Salmonella enterica]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDSEDALIQTVRERLSSPQKGIKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3V5VNJ7

Antitoxin

Source ID Structure
AlphaFold DB A0A5H5JRI5

References