Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3491285..3491905 Replicon chromosome
Accession NZ_CP101365
Organism Salmonella enterica strain SC2014107

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag NM059_RS17245 Protein ID WP_001280991.1
Coordinates 3491687..3491905 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag NM059_RS17240 Protein ID WP_000344807.1
Coordinates 3491285..3491659 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NM059_RS17230 (3486424) 3486424..3487617 + 1194 WP_001039202.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
NM059_RS17235 (3487640) 3487640..3490789 + 3150 WP_001132508.1 efflux RND transporter permease AcrB -
NM059_RS17240 (3491285) 3491285..3491659 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
NM059_RS17245 (3491687) 3491687..3491905 + 219 WP_001280991.1 HHA domain-containing protein Toxin
NM059_RS17250 (3492084) 3492084..3492635 + 552 WP_001278791.1 maltose O-acetyltransferase -
NM059_RS17255 (3492753) 3492753..3493223 + 471 WP_000136183.1 YlaC family protein -
NM059_RS17260 (3493279) 3493279..3493419 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
NM059_RS17265 (3493425) 3493425..3493685 - 261 WP_000801415.1 type B 50S ribosomal protein L31 -
NM059_RS17270 (3493910) 3493910..3495460 + 1551 WP_076932570.1 EAL domain-containing protein -
NM059_RS17280 (3495691) 3495691..3496080 + 390 WP_000961285.1 MGMT family protein -
NM059_RS17285 (3496113) 3496113..3496682 - 570 WP_000779802.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T251910 WP_001280991.1 NZ_CP101365:3491687-3491905 [Salmonella enterica]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT251910 WP_000344807.1 NZ_CP101365:3491285-3491659 [Salmonella enterica]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References