251909

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 2414985..2415507 Replicon chromosome
Accession NZ_CP101365
Organism Salmonella enterica strain SC2014107

Toxin (Protein)


Gene name stbE Uniprot ID V7IL40
Locus tag NM059_RS11840 Protein ID WP_000221345.1
Coordinates 2415223..2415507 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID V1H457
Locus tag NM059_RS11835 Protein ID WP_000885424.1
Coordinates 2414985..2415233 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NM059_RS11810 (2410621) 2410621..2411529 - 909 WP_079798353.1 LysR family transcriptional regulator -
NM059_RS11815 (2412446) 2412446..2413181 + 736 Protein_2311 helix-turn-helix domain-containing protein -
NM059_RS11820 (2413237) 2413237..2414145 - 909 WP_079798383.1 hypothetical protein -
NM059_RS11825 (2414296) 2414296..2414628 - 333 WP_000253155.1 DUF1493 family protein -
NM059_RS11830 (2414618) 2414618..2414833 - 216 WP_000206206.1 hypothetical protein -
NM059_RS11835 (2414985) 2414985..2415233 + 249 WP_000885424.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
NM059_RS11840 (2415223) 2415223..2415507 + 285 WP_000221345.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NM059_RS11845 (2415667) 2415667..2416056 + 390 WP_001652798.1 RidA family protein -
NM059_RS11850 (2416108) 2416108..2417187 - 1080 WP_000954688.1 S-adenosylmethionine:tRNA ribosyltransferase-isomerase -
NM059_RS11855 (2417380) 2417380..2417868 - 489 WP_001293638.1 MarR family winged helix-turn-helix transcriptional regulator -
NM059_RS11860 (2417913) 2417913..2419421 + 1509 WP_079798354.1 FAD-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2407749..2422278 14529
- flank IS/Tn - - 2412446..2413015 569


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11043.79 Da        Isoelectric Point: 10.6500

>T251909 WP_000221345.1 NZ_CP101365:2415223-2415507 [Salmonella enterica]
MTYKLAFNESALKEWKKLGHTIQEQFKKKLRERLENPRVPASQLHGRKDQYKIKLRGAGYRLVYSVEDEIITVTVIGVGK
RENDAVYKVTRHRS

Download         Length: 285 bp

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9090.32 Da        Isoelectric Point: 3.9820

>AT251909 WP_000885424.1 NZ_CP101365:2414985-2415233 [Salmonella enterica]
MAFQILTTTAASITELKRDPMGTFNAGDGAPVAILNRNEPAFYCVPPALYAHLMDILEDEELGRIIDERANERVIEVNID
DL

Download         Length: 249 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5Y2FFA8

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0WPN5

References