Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1002040..1002854 Replicon chromosome
Accession NZ_CP101365
Organism Salmonella enterica strain SC2014107

Toxin (Protein)


Gene name TacT3 Uniprot ID -
Locus tag NM059_RS04870 Protein ID WP_000971658.1
Coordinates 1002040..1002567 (-) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID M7S6I2
Locus tag NM059_RS04875 Protein ID WP_000855694.1
Coordinates 1002564..1002854 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NM059_RS04840 (998251) 998251..998648 + 398 Protein_947 cytoplasmic protein -
NM059_RS04845 (998839) 998839..999027 + 189 Protein_948 hypothetical protein -
NM059_RS04850 (999235) 999235..999903 + 669 WP_000445914.1 hypothetical protein -
NM059_RS04855 (999930) 999930..1000424 + 495 WP_000424948.1 hypothetical protein -
NM059_RS04860 (1000669) 1000669..1001325 - 657 WP_000420452.1 protein-serine/threonine phosphatase -
NM059_RS04865 (1001558) 1001558..1001967 + 410 Protein_952 IS5/IS1182 family transposase -
NM059_RS04870 (1002040) 1002040..1002567 - 528 WP_000971658.1 GNAT family N-acetyltransferase Toxin
NM059_RS04875 (1002564) 1002564..1002854 - 291 WP_000855694.1 DUF1778 domain-containing protein Antitoxin
NM059_RS04880 (1003124) 1003124..1003324 - 201 Protein_955 IS3 family transposase -
NM059_RS04885 (1003565) 1003565..1003891 + 327 WP_000393305.1 hypothetical protein -
NM059_RS04890 (1004164) 1004164..1004511 - 348 WP_001669174.1 DUF1493 family protein -
NM059_RS04895 (1004496) 1004496..1004945 - 450 WP_000381612.1 membrane protein -
NM059_RS04900 (1005377) 1005377..1005820 - 444 WP_079798511.1 SPI-1 type III secretion system invasion lipoprotein InvH -
NM059_RS04905 (1006276) 1006276..1006926 + 651 WP_001674874.1 type III secretion system transcriptional activator InvF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 1001827..1001967 140


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19051.87 Da        Isoelectric Point: 9.6420

>T251903 WP_000971658.1 NZ_CP101365:c1002567-1002040 [Salmonella enterica]
MMFTEWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSVQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Download         Length: 528 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10664.50 Da        Isoelectric Point: 6.3133

>AT251903 WP_000855694.1 NZ_CP101365:c1002854-1002564 [Salmonella enterica]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNVLPVAQKIVDAAERVYLTERDTQMIMEILDNPPAP
NEKLLAAAFALPDMKK

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A3V8SJE7

References