Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 860355..860980 Replicon chromosome
Accession NZ_CP101365
Organism Salmonella enterica strain SC2014107

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag NM059_RS04235 Protein ID WP_000911337.1
Coordinates 860582..860980 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID C0PXM4
Locus tag NM059_RS04230 Protein ID WP_000557545.1
Coordinates 860355..860582 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NM059_RS04200 (855451) 855451..856549 + 1099 WP_010989230.1 peptide chain release factor 2 -
NM059_RS04205 (856559) 856559..858076 + 1518 WP_000003339.1 lysine--tRNA ligase -
NM059_RS04210 (858152) 858152..858697 - 546 WP_050067887.1 isopentenyl-diphosphate Delta-isomerase -
NM059_RS04215 (858962) 858962..859720 + 759 WP_000244328.1 amidase activator ActS -
NM059_RS04225 (859966) 859966..860178 - 213 WP_024152440.1 hypothetical protein -
NM059_RS04230 (860355) 860355..860582 + 228 WP_000557545.1 toxin-antitoxin system antitoxin VapB Antitoxin
NM059_RS04235 (860582) 860582..860980 + 399 WP_000911337.1 tRNA(fMet)-specific endonuclease VapC Toxin
NM059_RS04240 (861789) 861789..862325 + 537 WP_001038503.1 STM3031 family outer membrane protein -
NM059_RS04245 (862372) 862372..863004 + 633 WP_000835265.1 YfdX family protein -
NM059_RS04250 (863723) 863723..864310 + 588 WP_001244643.1 fimbrial protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 860355..868770 8415


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-123)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 15037.43 Da        Isoelectric Point: 7.7785

>T251902 WP_000911337.1 NZ_CP101365:860582-860980 [Salmonella enterica]
MLKFMLDTNTCIFTIKNKPEHIRERFNLNTSRMCISSITLMELIYGAEKSLAPERNLAVVEGFISRLEVLDYDTQAAIHT
GQIRAELARKGTPVGPYDQMIAGHARSRGLVVVTNNLREFERIPGIRIEDWC

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8500.48 Da        Isoelectric Point: 5.0053

>AT251902 WP_000557545.1 NZ_CP101365:860355-860582 [Salmonella enterica]
MHTTLFFSNRTQAVRLPKSISFPDDVKHVEIIAVGRSRIITPVGESWDSWFDGEGASTDFMSTREQPAVQEREGF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0R9MGW6

References