Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 850627..851287 Replicon chromosome
Accession NZ_CP101365
Organism Salmonella enterica strain SC2014107

Toxin (Protein)


Gene name cptA Uniprot ID A0A5I5GR00
Locus tag NM059_RS04175 Protein ID WP_000244761.1
Coordinates 850874..851287 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S5MU13
Locus tag NM059_RS04170 Protein ID WP_000351186.1
Coordinates 850627..850893 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NM059_RS04150 (846555) 846555..847988 - 1434 WP_001230140.1 6-phospho-beta-glucosidase BglA -
NM059_RS04155 (848147) 848147..848458 + 312 WP_001182970.1 N(4)-acetylcytidine aminohydrolase -
NM059_RS04160 (848622) 848622..849281 + 660 WP_000250289.1 hemolysin III family protein -
NM059_RS04165 (849397) 849397..850377 - 981 WP_000874176.1 tRNA-modifying protein YgfZ -
NM059_RS04170 (850627) 850627..850893 + 267 WP_000351186.1 FAD assembly factor SdhE Antitoxin
NM059_RS04175 (850874) 850874..851287 + 414 WP_000244761.1 protein YgfX Toxin
NM059_RS04180 (851340) 851340..851861 - 522 WP_001055885.1 flavodoxin FldB -
NM059_RS04185 (851974) 851974..852870 + 897 WP_000434299.1 site-specific tyrosine recombinase XerD -
NM059_RS04190 (852894) 852894..853607 + 714 WP_000745615.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
NM059_RS04195 (853613) 853613..855346 + 1734 WP_000813394.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16199.15 Da        Isoelectric Point: 10.7537

>T251901 WP_000244761.1 NZ_CP101365:850874-851287 [Salmonella enterica]
VVLWQSDLRVSWRAQWISLLIHGLVSAVILLMPWPLSYTPLWMILLSLVVFDCVRSQRRINTCQGEIKLLMDGRLRWQGQ
DWTLLRPPWLLKSGMVLRLRAESGRHQHLWLAADSMEEAEWRELRRILLQQPISGQH

Download         Length: 414 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10550.05 Da        Isoelectric Point: 6.0783

>AT251901 WP_000351186.1 NZ_CP101365:850627-850893 [Salmonella enterica]
MDIHNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFVRLLQSDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5I5GR00

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0YWH4

References