Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 199826..200586 Replicon chromosome
Accession NZ_CP101365
Organism Salmonella enterica strain SC2014107

Toxin (Protein)


Gene name tacT Uniprot ID Q57IH1
Locus tag NM059_RS00950 Protein ID WP_000533909.1
Coordinates 200101..200586 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID M7RHS4
Locus tag NM059_RS00945 Protein ID WP_000965886.1
Coordinates 199826..200113 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NM059_RS00925 (195231) 195231..196142 + 912 WP_001168551.1 glycine--tRNA ligase subunit alpha -
NM059_RS00930 (196152) 196152..198221 + 2070 WP_001291739.1 glycine--tRNA ligase subunit beta -
NM059_RS00935 (198611) 198611..199009 + 399 Protein_185 IS3 family transposase -
NM059_RS00940 (199181) 199181..199648 + 468 WP_000702452.1 GNAT family N-acetyltransferase -
NM059_RS00945 (199826) 199826..200113 + 288 WP_000965886.1 DUF1778 domain-containing protein Antitoxin
NM059_RS00950 (200101) 200101..200586 + 486 WP_000533909.1 GNAT family N-acetyltransferase Toxin
NM059_RS00955 (200957) 200957..201496 - 540 WP_000047147.1 copper-binding periplasmic metallochaperone CueP -
NM059_RS00960 (201670) 201670..201882 - 213 WP_000014594.1 RNA chaperone/antiterminator CspA -
NM059_RS00965 (202171) 202171..202461 - 291 WP_000455790.1 HTH-type transcriptional regulator -
NM059_RS00970 (202900) 202900..203610 + 711 WP_000190524.1 DUF3053 domain-containing protein -
NM059_RS00975 (203660) 203660..204634 - 975 WP_000804683.1 glyoxylate/hydroxypyruvate reductase GhrB -
NM059_RS00980 (204853) 204853..205515 - 663 WP_000747548.1 OmpA family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(31-152)

Antitoxin

Vibrio phage ICP1, Orf50

(5-94)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17703.41 Da        Isoelectric Point: 9.8719

>T251900 WP_000533909.1 NZ_CP101365:200101-200586 [Salmonella enterica]
VGRVTAPEPLSAFHQVAEFVSGEAVLDDWLKQKGLKNQALGAARTFVVCKKDTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDLSFHGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKSSQTQQRTLFLRLP
Q

Download         Length: 486 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10950.60 Da        Isoelectric Point: 4.6811

>AT251900 WP_000965886.1 NZ_CP101365:199826-200113 [Salmonella enterica]
MLYKGCLMKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILETACQAAEKVILDRRVFNFNDEQYEEFINLLDAPVADD
PVIEKLLARKPQWDV

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7F36
PDB 7AK8
PDB 5FVJ

Antitoxin

Source ID Structure
PDB 7AK8
AlphaFold DB A0A3V2JDX2

References