Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 4788474..4789069 Replicon chromosome
Accession NZ_CP101310
Organism Escherichia coli strain 99-3311

Toxin (Protein)


Gene name chpB Uniprot ID U9Y4M4
Locus tag NMK62_RS23785 Protein ID WP_000239579.1
Coordinates 4788474..4788824 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID U9Y2K1
Locus tag NMK62_RS23790 Protein ID WP_001223208.1
Coordinates 4788818..4789069 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NMK62_RS23765 (4783920) 4783920..4784942 - 1023 WP_001400707.1 ABC transporter permease -
NMK62_RS23770 (4784956) 4784956..4786458 - 1503 WP_000205816.1 sugar ABC transporter ATP-binding protein -
NMK62_RS23775 (4786598) 4786598..4787554 - 957 WP_000265940.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
NMK62_RS23780 (4787864) 4787864..4788394 + 531 WP_000055075.1 inorganic diphosphatase -
NMK62_RS23785 (4788474) 4788474..4788824 - 351 WP_000239579.1 endoribonuclease toxin ChpB Toxin
NMK62_RS23790 (4788818) 4788818..4789069 - 252 WP_001223208.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
NMK62_RS23795 (4789281) 4789281..4789622 - 342 WP_001219160.1 gamma-glutamylcyclotransferase -
NMK62_RS23800 (4789625) 4789625..4793404 - 3780 WP_000060846.1 autotransporter assembly complex protein TamB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12511.45 Da        Isoelectric Point: 5.6219

>T251897 WP_000239579.1 NZ_CP101310:c4788824-4788474 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9271.58 Da        Isoelectric Point: 4.4201

>AT251897 WP_001223208.1 NZ_CP101310:c4789069-4788818 [Escherichia coli]
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y8A8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LQ26

References