Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4076116..4076734 Replicon chromosome
Accession NZ_CP101310
Organism Escherichia coli strain 99-3311

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag NMK62_RS20565 Protein ID WP_001291435.1
Coordinates 4076516..4076734 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag NMK62_RS20560 Protein ID WP_000344800.1
Coordinates 4076116..4076490 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NMK62_RS20550 (4071205) 4071205..4072398 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
NMK62_RS20555 (4072421) 4072421..4075570 + 3150 WP_001132469.1 efflux RND transporter permease AcrB -
NMK62_RS20560 (4076116) 4076116..4076490 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
NMK62_RS20565 (4076516) 4076516..4076734 + 219 WP_001291435.1 HHA domain-containing protein Toxin
NMK62_RS20570 (4076906) 4076906..4077457 + 552 WP_000102564.1 maltose O-acetyltransferase -
NMK62_RS20575 (4077573) 4077573..4078043 + 471 WP_000136192.1 YlaC family protein -
NMK62_RS20580 (4078207) 4078207..4079757 + 1551 WP_024221674.1 cyclic-guanylate-specific phosphodiesterase PdeB -
NMK62_RS20585 (4079799) 4079799..4080152 - 354 WP_000878140.1 DUF1428 domain-containing protein -
NMK62_RS20595 (4080531) 4080531..4080842 + 312 WP_000409911.1 MGMT family protein -
NMK62_RS20600 (4080873) 4080873..4081445 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T251895 WP_001291435.1 NZ_CP101310:4076516-4076734 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT251895 WP_000344800.1 NZ_CP101310:4076116-4076490 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References