Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2621059..2621697 Replicon chromosome
Accession NZ_CP101310
Organism Escherichia coli strain 99-3311

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag NMK62_RS13005 Protein ID WP_000813794.1
Coordinates 2621521..2621697 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag NMK62_RS13000 Protein ID WP_001270286.1
Coordinates 2621059..2621475 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NMK62_RS12980 (2616210) 2616210..2617151 - 942 WP_001251328.1 ABC transporter permease -
NMK62_RS12985 (2617152) 2617152..2618165 - 1014 WP_000220414.1 ABC transporter ATP-binding protein -
NMK62_RS12990 (2618183) 2618183..2619328 - 1146 WP_000335342.1 ABC transporter substrate-binding protein -
NMK62_RS12995 (2619574) 2619574..2620980 - 1407 WP_000760665.1 PLP-dependent aminotransferase family protein -
NMK62_RS13000 (2621059) 2621059..2621475 - 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
NMK62_RS13005 (2621521) 2621521..2621697 - 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
NMK62_RS13010 (2621919) 2621919..2622149 + 231 WP_000494244.1 YncJ family protein -
NMK62_RS13015 (2622241) 2622241..2624202 - 1962 WP_000218823.1 23S rRNA 5-hydroxycytidine C2501 synthase -
NMK62_RS13020 (2624275) 2624275..2624811 - 537 WP_000429147.1 DNA-binding transcriptional regulator SutR -
NMK62_RS13025 (2624903) 2624903..2626075 + 1173 WP_001236321.1 BenE family transporter YdcO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T251892 WP_000813794.1 NZ_CP101310:c2621697-2621521 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT251892 WP_001270286.1 NZ_CP101310:c2621475-2621059 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References