Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ataRT/DUF1778(antitoxin)
Location 393422..394176 Replicon chromosome
Accession NZ_CP101310
Organism Escherichia coli strain 99-3311

Toxin (Protein)


Gene name ataT Uniprot ID A0A7U9LH62
Locus tag NMK62_RS01910 Protein ID WP_001400419.1
Coordinates 393422..393907 (-) Length 162 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID Q8X700
Locus tag NMK62_RS01915 Protein ID WP_000801912.1
Coordinates 393898..394176 (-) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NMK62_RS01890 (388587) 388587..389345 + 759 WP_000815099.1 DeoR/GlpR family transcriptional regulator -
NMK62_RS01895 (389327) 389327..390925 - 1599 WP_001232936.1 DNA-binding transcriptional regulator RtcR -
NMK62_RS01900 (391114) 391114..392340 + 1227 WP_001105483.1 RNA-splicing ligase RtcB -
NMK62_RS01905 (392344) 392344..393372 + 1029 WP_024221621.1 RNA 3'-terminal phosphate cyclase -
NMK62_RS01910 (393422) 393422..393907 - 486 WP_001400419.1 GNAT family N-acetyltransferase Toxin
NMK62_RS01915 (393898) 393898..394176 - 279 WP_000801912.1 DUF1778 domain-containing protein Antitoxin
NMK62_RS01920 (394243) 394243..396948 - 2706 WP_000906970.1 HTH-type transcriptional regulator MalT -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(49-143)

Antitoxin

Vibrio phage ICP1, Orf50

(2-92)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17692.65 Da        Isoelectric Point: 9.4066

>T251881 WP_001400419.1 NZ_CP101310:c393907-393422 [Escherichia coli]
MGITAPTPLTSEHNLADFCCSDHGMNEWLKKKALKNHSTGLSRVYVICIVNTRQVIGYYCLSTGSIQRNLAPGAMRRNAP
ESLPVVVLGRLAIDQAWAGKGLGVALLKDAVYRTMSIAQQVGVRALIVHALDDSVRNFYLKYAFVPSPFQSLTLLYPITL
E

Download         Length: 486 bp

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10420.94 Da        Isoelectric Point: 4.6336

>AT251881 WP_000801912.1 NZ_CP101310:c394176-393898 [Escherichia coli]
MKPESKEAPINIRAKASQRDLIDMAANLVAKSRTDFMLDAACREAQDILLDQRLFILDDEQYDAFLAALDAPITAERQAK
INALMNRKSPWE

Download         Length: 279 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LH62

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LHB9

References