Detailed information of TA system TA025188

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazEF/MazE-MazF
• Location: 1234198..1234775
• Replicon: chromosome
• Accession: NC_015388
• Organism: Desulfobacca acetoxidans DSM 11109

Toxin (Protein)

• Gene name: mazF
• Uniprot ID: F2NH90
• Locus tag: DESAC_RS05290
• Protein ID: WP_013706044.1
• Coordinates: 1234198..1234446 (+)
• Length: 83 a.a.

Antitoxin (Protein)

• Gene name: mazE
• Uniprot ID: -
• Locus tag: DESAC_RS05295
• Protein ID: WP_013706045.1
• Coordinates: 1234452..1234775 (+)
• Length: 108 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DESAC_RS05285	1230662..1233358	-	2697	WP_013706043.1	formate dehydrogenase subunit alpha	-
DESAC_RS05290	1234198..1234446	+	249	WP_013706044.1	SpoVT/AbrB domain-containing protein	Toxin
DESAC_RS05295	1234452..1234775	+	324	WP_013706045.1	type II toxin-antitoxin system PemK/MazF family toxin	Antitoxin
DESAC_RS05300	1234830..1236671	-	1842	WP_013706046.1	NADH-quinone oxidoreductase subunit NuoF	-
DESAC_RS05305	1236685..1239378	-	2694	WP_013706047.1	formate dehydrogenase subunit alpha	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	1228748..1242002	13254

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• mRNA interferase PemK-like (2-105)

Sequences

Toxin

Protein

• Length: 83 a.a.
• Molecular weight: 9235.75 Da
• Isoelectric Point: 7.2045

>T25188 WP_013706044.1 NC_015388:1234198-1234446 [Desulfobacca acetoxidans DSM 11109]
MKTKLIPIGNSKGVRLPKPLLLQAGLTDEVELHVQDGAIVIVRASTPRAGWAKAAQELRHRKEDVLIEPLTPTIFDEKDW
EW

Nucleotide

• Length: 249 bp

>T25188 NC_015388:1234198-1234446 [Desulfobacca acetoxidans DSM 11109]
ATGAAAACAAAGTTGATTCCCATTGGCAACTCAAAAGGAGTTCGGTTGCCCAAACCTCTCCTCTTACAAGCCGGTTTAAC
CGACGAAGTGGAACTGCATGTGCAGGATGGCGCTATTGTGATTGTGCGGGCCTCAACCCCACGCGCCGGGTGGGCTAAAG
CCGCCCAGGAGTTGCGTCATCGGAAAGAAGATGTCTTGATAGAACCGCTTACCCCCACTATTTTTGACGAAAAAGATTGG
GAATGGTGA

Antitoxin

Protein

• Length: 108 a.a.
• Molecular weight: 12034.04 Da
• Isoelectric Point: 7.1355

>AT25188 WP_013706045.1 NC_015388:1234452-1234775 [Desulfobacca acetoxidans DSM 11109]
MEIRRGDVFLVSLDPPQGGEIQKTRPCIIISPDELNTHLRTFIVAPLTTGGHPYPFRLPCQFEGKAGFVVLDQIRTVDRG
RLVRRLGELPPDVLGRILETLQEMFAP

Nucleotide

• Length: 324 bp

>AT25188 NC_015388:1234452-1234775 [Desulfobacca acetoxidans DSM 11109]
ATGGAAATTCGACGCGGCGACGTGTTTTTGGTCAGTCTTGACCCGCCTCAAGGGGGCGAGATCCAAAAGACCCGCCCTTG
TATCATTATTTCTCCTGATGAACTGAATACCCATTTGCGAACCTTCATCGTGGCTCCCTTGACTACAGGCGGCCATCCCT
ATCCCTTCCGCTTACCTTGTCAATTCGAAGGTAAAGCCGGCTTCGTGGTTCTCGACCAGATTCGCACCGTGGACCGAGGG
CGTTTGGTGCGGCGACTGGGGGAACTCCCTCCTGACGTCCTGGGCCGGATATTGGAGACCTTACAGGAAATGTTTGCCCC
CTAG

Structures

Toxin

• AlphaFold DB: F2NH90