Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 303839..304470 Replicon chromosome
Accession NZ_CP101310
Organism Escherichia coli strain 99-3311

Toxin (Protein)


Gene name hicA Uniprot ID A0A7U9LJQ2
Locus tag NMK62_RS01435 Protein ID WP_001259387.1
Coordinates 303839..304114 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID U9Y7E1
Locus tag NMK62_RS01440 Protein ID WP_000593555.1
Coordinates 304111..304470 (+) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NMK62_RS01420 (298843) 298843..299910 + 1068 WP_000361517.1 HlyD family efflux transporter periplasmic adaptor subunit -
NMK62_RS01425 (299907) 299907..302642 + 2736 WP_022581203.1 ribosome-associated ATPase/putative transporter RbbA -
NMK62_RS01430 (302642) 302642..303766 + 1125 WP_001314210.1 ABC transporter permease -
NMK62_RS01435 (303839) 303839..304114 + 276 WP_001259387.1 type II toxin-antitoxin system HicA family toxin Toxin
NMK62_RS01440 (304111) 304111..304470 + 360 WP_000593555.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
NMK62_RS01445 (304520) 304520..305380 - 861 WP_001131788.1 class II aldolase -
NMK62_RS01450 (305412) 305412..305681 - 270 WP_000933061.1 HPr family phosphocarrier protein -
NMK62_RS01455 (305671) 305671..307179 - 1509 WP_001400448.1 FGGY-family carbohydrate kinase -
NMK62_RS01460 (307172) 307172..308530 - 1359 WP_001308116.1 PTS galactitol transporter subunit IIC -
NMK62_RS01465 (308607) 308607..308888 - 282 WP_000084022.1 PTS sugar transporter subunit IIB -
NMK62_RS01470 (308885) 308885..309358 - 474 WP_001161553.1 PTS sugar transporter subunit IIA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(30-80)

Antitoxin

Uncharacterised protein family HicB

(60-112)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10214.91 Da        Isoelectric Point: 10.7076

>T251879 WP_001259387.1 NZ_CP101310:303839-304114 [Escherichia coli]
MRTKVQALRKKQKNTLDQIFKTPVPQGIKWSDIESQVKALGGEIKEGRGSRCKFILNMSVACFHRPHPSPDTDKGAVESV
RDWLLSIGVKP

Download         Length: 276 bp

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13402.27 Da        Isoelectric Point: 5.1987

>AT251879 WP_000593555.1 NZ_CP101310:304111-304470 [Escherichia coli]
MIKLKTPNSMEIAGQPAVITYVPELNAFRGKFLGLSGYCDFVSDSIQGLQKEGELSLREYLEDCKAAGIEPYARTEKIKT
FTLRYPESLSERLNNAAAQQQVSVNTYIIETLNERLNHL

Download         Length: 360 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LJQ2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LKZ6

References