Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PanAT/DUF4065(antitoxin)
Location 5000043..5000968 Replicon chromosome
Accession NZ_CP101305
Organism Escherichia coli strain 2002-3211

Toxin (Protein)


Gene name panT Uniprot ID -
Locus tag NMK57_RS25165 Protein ID WP_014640052.1
Coordinates 5000043..5000429 (-) Length 129 a.a.

Antitoxin (Protein)


Gene name panA Uniprot ID -
Locus tag NMK57_RS25170 Protein ID WP_024174200.1
Coordinates 5000459..5000968 (-) Length 170 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NMK57_RS25115 (4996151) 4996151..4996537 + 387 Protein_4918 5'-deoxynucleotidase -
NMK57_RS25120 (4996528) 4996528..4996878 + 351 WP_001242740.1 hypothetical protein -
NMK57_RS25125 (4996875) 4996875..4997348 + 474 WP_000145671.1 class I SAM-dependent methyltransferase -
NMK57_RS25130 (4997495) 4997495..4997962 + 468 WP_000829413.1 hypothetical protein -
NMK57_RS25135 (4997964) 4997964..4998155 + 192 WP_001014294.1 hypothetical protein -
NMK57_RS25140 (4998158) 4998158..4998454 + 297 Protein_4923 DUF551 domain-containing protein -
NMK57_RS25145 (4998701) 4998701..4998892 + 192 WP_001690200.1 DUF551 domain-containing protein -
NMK57_RS25150 (4998892) 4998892..4999464 + 573 WP_001061339.1 3'-5' exonuclease -
NMK57_RS25155 (4999501) 4999501..4999782 + 282 WP_001093921.1 pyocin activator PrtN family protein -
NMK57_RS25160 (4999830) 4999830..5000003 - 174 WP_000390069.1 hypothetical protein -
NMK57_RS25165 (5000043) 5000043..5000429 - 387 WP_014640052.1 hypothetical protein Toxin
NMK57_RS25170 (5000459) 5000459..5000968 - 510 WP_024174200.1 Panacea domain-containing protein Antitoxin
NMK57_RS25175 (5001284) 5001284..5001388 - 105 Protein_4930 tRNA-dihydrouridine synthase -
NMK57_RS25180 (5001751) 5001751..5002737 - 987 WP_000912572.1 DUF2713 domain-containing protein -
NMK57_RS25185 (5003055) 5003055..5003570 + 516 WP_001295691.1 zinc uptake transcriptional repressor Zur -
NMK57_RS25190 (5003612) 5003612..5003821 - 210 WP_001030593.1 CsbD family protein -
NMK57_RS25195 (5003937) 5003937..5005262 - 1326 WP_001370252.1 MATE family efflux transporter DinF -
NMK57_RS25200 (5005335) 5005335..5005943 - 609 WP_000646078.1 transcriptional repressor LexA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - nleG7' 4943993..5005943 61950


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Antitoxin SocA-like, Panacea domain

(6-116)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14465.40 Da        Isoelectric Point: 5.4833

>T251876 WP_014640052.1 NZ_CP101305:c5000429-5000043 [Escherichia coli]
VLAPTGPCNHLHVICNDPVYYPVNDCYCVLVVNISSIKDGVPHDPSCVLNSGDHRFIKHPSYVVYAEAIIWRVDNMVRKQ
RSGEISVHDDMPEATFNRILDGFDISDEVTPKNLKFKNKYCVSSIDDE

Download         Length: 387 bp

Antitoxin


Download         Length: 170 a.a.        Molecular weight: 19559.39 Da        Isoelectric Point: 5.3338

>AT251876 WP_024174200.1 NZ_CP101305:c5000968-5000459 [Escherichia coli]
MAYLKLMKLLYLSNRKSILKHGRMIGEDSLYSMKFGPVMSNTLNLIRGKAEGIGDYWYNLIETNGHDVLLRSDPREMDAD
EVFDELSRADIRILDEIYSLYGHMNRFDLANMTHLESVCPEWHNPGNSRKPIDLKEMLISEGKSEDEANRIIGKMEESQK
LKEFSLQLS

Download         Length: 510 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References