Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type V Classification (family/domain) ghoTS/ghoT-GhoS
Location 4857497..4857994 Replicon chromosome
Accession NZ_CP101305
Organism Escherichia coli strain 2002-3211

Toxin (Protein)


Gene name ghoT Uniprot ID L4JJG6
Locus tag NMK57_RS24390 Protein ID WP_001173343.1
Coordinates 4857497..4857670 (-) Length 58 a.a.

Antitoxin (Protein)


Gene name ghoS Uniprot ID A0A3W5Y3H9
Locus tag NMK57_RS24395 Protein ID WP_071532590.1
Coordinates 4857698..4857994 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NMK57_RS24380 (4854167) 4854167..4855624 + 1458 WP_000856834.1 dipeptide/tripeptide permease DtpC -
NMK57_RS24385 (4855861) 4855861..4857378 + 1518 WP_001295082.1 lysine--tRNA ligase -
NMK57_RS24390 (4857497) 4857497..4857670 - 174 WP_001173343.1 type V toxin-antitoxin system toxin GhoT Toxin
NMK57_RS24395 (4857698) 4857698..4857994 - 297 WP_071532590.1 type V toxin-antitoxin system endoribonuclease antitoxin GhoS Antitoxin
NMK57_RS24400 (4858221) 4858221..4858493 - 273 WP_000405647.1 GNAT family N-acetyltransferase -
NMK57_RS24405 (4858505) 4858505..4858735 - 231 WP_000371698.1 4Fe-4S mono-cluster protein YjdI -
NMK57_RS24410 (4858916) 4858916..4860547 + 1632 WP_001216468.1 sensor histidine kinase -
NMK57_RS24415 (4860544) 4860544..4861263 + 720 WP_000611288.1 two-component system response regulator DcuR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin GhoT/OrtT

(4-57)

Antitoxin

Endoribonuclease antitoxin GhoS

(7-94)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6555.06 Da        Isoelectric Point: 10.2288

>T251875 WP_001173343.1 NZ_CP101305:c4857670-4857497 [Escherichia coli]
MALFSKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF

Download         Length: 174 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11482.04 Da        Isoelectric Point: 4.2931

>AT251875 WP_071532590.1 NZ_CP101305:c4857994-4857698 [Escherichia coli]
MEGKKKFNTYVVSFDYPSSYSSVFLRLRSLMYDMNFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDI
DFDLNIMTVDDYFRQFYK

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9QI41

Antitoxin

Source ID Structure
AlphaFold DB A0A3W5Y3H9

References