Detailed information of TA system TA025187

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relE-pasA/RelE-HTH
• Location: 62724..63201
• Replicon: chromosome
• Accession: NC_015388
• Organism: Desulfobacca acetoxidans DSM 11109

Toxin (Protein)

• Gene name: relE
• Uniprot ID: F2NJ03
• Locus tag: DESAC_RS00315
• Protein ID: WP_013705076.1
• Coordinates: 62935..63201 (+)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: pasA
• Uniprot ID: F2NJ02
• Locus tag: DESAC_RS00310
• Protein ID: WP_013705075.1
• Coordinates: 62724..62951 (+)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DESAC_RS00260	57969..58226	+	258	WP_013705066.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	-
DESAC_RS00265	58223..58624	+	402	WP_013705067.1	type II toxin-antitoxin system VapC family toxin	-
DESAC_RS00270	58639..58844	+	206	Protein_52	2-oxoisovalerate dehydrogenase	-
DESAC_RS00275	58932..59228	+	297	WP_013705069.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	-
DESAC_RS00280	59225..59605	+	381	WP_013705070.1	putative toxin-antitoxin system toxin component, PIN family	-
DESAC_RS00290	60031..60465	-	435	WP_013705071.1	putative toxin-antitoxin system toxin component, PIN family	-
DESAC_RS00295	60476..60769	-	294	WP_013705072.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-
DESAC_RS00300	60944..61216	-	273	WP_013705073.1	HU family DNA-binding protein	-
DESAC_RS00305	61239..62585	-	1347	WP_148231263.1	DEAD/DEAH box helicase	-
DESAC_RS00310	62724..62951	+	228	WP_013705075.1	ribbon-helix-helix protein, CopG family	Antitoxin
DESAC_RS00315	62935..63201	+	267	WP_013705076.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
DESAC_RS00320	63194..63388	+	195	WP_013705077.1	hypothetical protein	-
DESAC_RS00325	63742..65862	+	2121	WP_013705078.1	TonB-dependent receptor	-
DESAC_RS00330	65887..66594	+	708	WP_013705079.1	DUF4198 domain-containing protein	-
DESAC_RS14850	66643..67152	+	510	WP_013705080.1	hypothetical protein	-
DESAC_RS00340	67162..68025	+	864	WP_013705081.1	tetrapyrrole methylase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10052.54 Da
• Isoelectric Point: 7.9731

>T25187 WP_013705076.1 NC_015388:62935-63201 [Desulfobacca acetoxidans DSM 11109]
MAWKIEYSRTARKQLWELDLQKARNVLAFGDDLAKQENPRDMGKALSGPMGTLWSYRLGGIRLICDLQDDLARIQVLRLG
EFKEGDNG

Nucleotide

• Length: 267 bp

>T25187 NC_015388:62935-63201 [Desulfobacca acetoxidans DSM 11109]
TTGGCCTGGAAGATTGAGTATTCCCGGACTGCCAGAAAGCAGCTGTGGGAGCTGGACCTGCAAAAAGCCAGGAATGTGCT
TGCATTTGGCGACGATCTGGCAAAACAGGAGAATCCCCGGGATATGGGGAAGGCCCTCAGTGGCCCTATGGGGACTTTAT
GGAGTTATCGGCTGGGAGGAATTCGTTTGATCTGTGACCTGCAAGACGACTTGGCCCGTATCCAAGTCTTGCGCCTGGGG
GAATTTAAGGAAGGAGATAATGGCTAA

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8718.84 Da
• Isoelectric Point: 4.8232

>AT25187 WP_013705075.1 NC_015388:62724-62951 [Desulfobacca acetoxidans DSM 11109]
MSVSVRLPDDLNNRLDFLARQTGRTKTYYILEALYAQIDELESYYLAADVLERLRKKKETAHAADEVRKDLGLED

Nucleotide

• Length: 228 bp

>AT25187 NC_015388:62724-62951 [Desulfobacca acetoxidans DSM 11109]
ATGTCGGTATCGGTGCGGCTGCCAGATGATCTCAATAACCGACTGGATTTTTTGGCGCGCCAGACCGGCCGCACCAAGAC
ATATTATATTCTGGAGGCGCTCTACGCCCAGATCGACGAGCTGGAGAGCTATTATCTGGCCGCCGATGTCCTTGAGCGCC
TGCGAAAGAAAAAAGAAACTGCCCATGCCGCTGATGAAGTGAGGAAGGACCTTGGCCTGGAAGATTGA

Structures

Toxin

• AlphaFold DB: F2NJ03

Antitoxin

• AlphaFold DB: F2NJ02