Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1459374..1459999 Replicon chromosome
Accession NZ_CP101305
Organism Escherichia coli strain 2002-3211

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag NMK57_RS07200 Protein ID WP_000911330.1
Coordinates 1459601..1459999 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID U9XQV3
Locus tag NMK57_RS07195 Protein ID WP_000450524.1
Coordinates 1459374..1459601 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NMK57_RS07170 (1455177) 1455177..1455647 - 471 WP_001068682.1 thioredoxin-dependent thiol peroxidase -
NMK57_RS07175 (1455647) 1455647..1456219 - 573 WP_000176187.1 glycine cleavage system transcriptional repressor -
NMK57_RS07180 (1456365) 1456365..1457243 + 879 WP_001295469.1 4-hydroxy-tetrahydrodipicolinate synthase -
NMK57_RS07185 (1457260) 1457260..1458294 + 1035 WP_001297320.1 outer membrane protein assembly factor BamC -
NMK57_RS07190 (1458507) 1458507..1459220 + 714 WP_001295467.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
NMK57_RS07195 (1459374) 1459374..1459601 + 228 WP_000450524.1 toxin-antitoxin system antitoxin VapB Antitoxin
NMK57_RS07200 (1459601) 1459601..1459999 + 399 WP_000911330.1 type II toxin-antitoxin system VapC family toxin Toxin
NMK57_RS07205 (1460146) 1460146..1461009 + 864 WP_001267498.1 neutral zinc metallopeptidase -
NMK57_RS07210 (1461024) 1461024..1463039 + 2016 WP_000829325.1 tRNA cytosine(34) acetyltransferase TmcA -
NMK57_RS07215 (1463113) 1463113..1463810 + 698 Protein_1412 esterase -
NMK57_RS07220 (1463920) 1463920..1464120 - 201 WP_000383836.1 YpfN family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14894.25 Da        Isoelectric Point: 9.2216

>T251863 WP_000911330.1 NZ_CP101305:1459601-1459999 [Escherichia coli]
MLKFMLDTNICIFTIKNKPVHVRERFNLNSGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRLVVLDYDSAAATHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIVVTNNTREFERVAGIRLEDWS

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8498.61 Da        Isoelectric Point: 4.3867

>AT251863 WP_000450524.1 NZ_CP101305:1459374-1459601 [Escherichia coli]
METTVFLSNRSQAVRLPKAVALPEDVKKVEIIAIGRTRIITPAGESWDSWFDGENVSADFMDIRDQPAMQERESF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A829CM33

References