251852

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 5211034..5211665 Replicon chromosome
Accession NZ_CP101302
Organism Escherichia coli strain 2000-3039

Toxin (Protein)


Gene name hicA Uniprot ID U9Y2A7
Locus tag NMK59_RS26285 Protein ID WP_001259385.1
Coordinates 5211390..5211665 (-) Length 92 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID Q31VE4
Locus tag NMK59_RS26280 Protein ID WP_000593554.1
Coordinates 5211034..5211393 (-) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NMK59_RS26250 (5206146) 5206146..5206619 + 474 WP_001161553.1 PTS sugar transporter subunit IIA -
NMK59_RS26255 (5206616) 5206616..5206897 + 282 WP_000084022.1 PTS sugar transporter subunit IIB -
NMK59_RS26260 (5206974) 5206974..5208332 + 1359 WP_001298729.1 PTS galactitol transporter subunit IIC -
NMK59_RS26265 (5208325) 5208325..5209833 + 1509 WP_001298718.1 FGGY-family carbohydrate kinase -
NMK59_RS26270 (5209823) 5209823..5210092 + 270 WP_000933060.1 HPr family phosphocarrier protein -
NMK59_RS26275 (5210124) 5210124..5210984 + 861 WP_001131783.1 class II aldolase -
NMK59_RS26280 (5211034) 5211034..5211393 - 360 WP_000593554.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
NMK59_RS26285 (5211390) 5211390..5211665 - 276 WP_001259385.1 type II toxin-antitoxin system HicA family toxin Toxin
NMK59_RS26290 (5211738) 5211738..5212862 - 1125 WP_001216257.1 ABC transporter permease -
NMK59_RS26295 (5212862) 5212862..5215597 - 2736 WP_000149167.1 ribosome-associated ATPase/putative transporter RbbA -
NMK59_RS26300 (5215594) 5215594..5216661 - 1068 WP_000361467.1 HlyD family secretion protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(30-80)

Antitoxin

Uncharacterised protein family HicB

(60-112)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10199.94 Da        Isoelectric Point: 10.7076

>T251852 WP_001259385.1 NZ_CP101302:c5211665-5211390 [Escherichia coli]
MRTKVQALRKKQKNTLDQIFKTPVPQGIKWSDIESLVKALGGEIKEGRGSRCKFILNMSVACFHRPHPSPDTDKGAVESV
RDWLLSIGVKP

Download         Length: 276 bp

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13359.25 Da        Isoelectric Point: 4.8838

>AT251852 WP_000593554.1 NZ_CP101302:c5211393-5211034 [Escherichia coli]
MIKLKTPNSMEIAGQPAVITYVPELNAFRGKFLGLSGYCDFVSDSIQGLQKEGELSLLEYLEDCKAAGIEPYARTEKIKT
FTLRYPESLSERLNNAAAQQQVSVNTYIIETLNERLNHL

Download         Length: 360 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4P7TTW8

Antitoxin

Source ID Structure
AlphaFold DB A0A6H2GM94

References