Detailed information of TA system TA025185

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ-RelB
• Location: 1909202..1909752
• Replicon: chromosome
• Accession: NC_015385
• Organism: Treponema succinifaciens DSM 2489

Toxin (Protein)

• Gene name: relE
• Uniprot ID: F2NT77
• Locus tag: TRESU_RS09040
• Protein ID: WP_013701949.1
• Coordinates: 1909202..1909492 (-)
• Length: 97 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: F2NT78
• Locus tag: TRESU_RS09045
• Protein ID: WP_013701950.1
• Coordinates: 1909486..1909752 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
TRESU_RS09030	1905633..1907138	+	1506	WP_013701947.1	glycine hydroxymethyltransferase	-
TRESU_RS09035	1907689..1909086	+	1398	WP_013701948.1	hypothetical protein	-
TRESU_RS09040	1909202..1909492	-	291	WP_013701949.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	Toxin
TRESU_RS09045	1909486..1909752	-	267	WP_013701950.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
TRESU_RS09050	1909809..1910090	-	282	WP_013701951.1	GNAT family N-acetyltransferase	-
TRESU_RS14940	1910123..1910215	-	93	WP_169309754.1	DUF3781 domain-containing protein	-
TRESU_RS09055	1910208..1911218	-	1011	WP_013701952.1	hypothetical protein	-
TRESU_RS09060	1911215..1911511	-	297	WP_013701953.1	hypothetical protein	-
TRESU_RS09065	1911606..1911962	-	357	WP_013701954.1	PIN domain-containing protein	-
TRESU_RS09070	1911965..1912180	-	216	WP_013701955.1	hypothetical protein	-
TRESU_RS14300	1912497..1913636	-	1140	WP_013701956.1	ankyrin repeat domain-containing protein	-
TRESU_RS09080	1913724..1914551	-	828	WP_013701957.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	1651245..1916597	265352

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (5-94)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (6-81)

Sequences

Toxin

Protein

• Length: 97 a.a.
• Molecular weight: 11629.50 Da
• Isoelectric Point: 9.3059

>T25185 WP_013701949.1 NC_015385:c1909492-1909202 [Treponema succinifaciens DSM 2489]
MVEPKYQIKWTSQYKKDIKLAKKRHYKIEELQKVVFSLANALPLDEKYHDHELEGNWKNHRECHIKPDWLLIYQIKDDVL
ILELSRTGTHADLFKK

Nucleotide

• Length: 291 bp

>T25185 NC_015385:c1909492-1909202 [Treponema succinifaciens DSM 2489]
ATGGTAGAACCAAAATATCAAATCAAGTGGACTTCGCAATACAAAAAAGACATAAAACTTGCAAAAAAACGACATTACAA
AATTGAAGAATTACAAAAAGTTGTCTTTTCGCTCGCAAACGCTCTTCCTCTCGATGAAAAATACCACGACCACGAGCTTG
AGGGAAACTGGAAAAATCACCGTGAATGTCACATAAAACCGGACTGGCTTTTAATTTATCAGATAAAAGATGATGTGCTG
ATTCTTGAACTTTCACGCACAGGAACTCACGCTGATTTATTTAAAAAATAG

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10119.55 Da
• Isoelectric Point: 6.3166

>AT25185 WP_013701950.1 NC_015385:c1909752-1909486 [Treponema succinifaciens DSM 2489]
MANLTITLDDQDKKDISSFCEQVGMTVSGLYNVFTKQVLREGRIPFDVAVDRPNRKTIKAMKEGDRIANDPNVKGYSFNE
FVEEMKKW

Nucleotide

• Length: 267 bp

>AT25185 NC_015385:c1909752-1909486 [Treponema succinifaciens DSM 2489]
ATGGCAAACTTGACAATCACTTTGGATGACCAGGACAAAAAAGACATCTCATCATTCTGCGAGCAGGTCGGAATGACTGT
TTCAGGGCTTTACAACGTTTTTACAAAACAAGTTCTCCGCGAAGGACGGATTCCGTTCGACGTAGCCGTTGACCGCCCTA
ACCGCAAGACAATCAAGGCAATGAAAGAAGGCGACAGAATTGCGAACGACCCGAATGTGAAAGGATACTCATTTAATGAA
TTTGTCGAGGAGATGAAAAAATGGTAG

Structures

Toxin

• AlphaFold DB: F2NT77

Antitoxin

• AlphaFold DB: F2NT78