Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
| Location | 4592790..4593588 | Replicon | chromosome |
| Accession | NZ_CP101302 | ||
| Organism | Escherichia coli strain 2000-3039 | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | A0A0F3UPG9 |
| Locus tag | NMK59_RS23115 | Protein ID | WP_000854698.1 |
| Coordinates | 4593211..4593588 (+) | Length | 126 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | A0A0F3T7G0 |
| Locus tag | NMK59_RS23110 | Protein ID | WP_000017094.1 |
| Coordinates | 4592790..4593164 (+) | Length | 125 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| NMK59_RS23080 (4589657) | 4589657..4590097 | + | 441 | Protein_4516 | DUF945 domain-containing protein | - |
| NMK59_RS23085 (4590188) | 4590188..4590673 | + | 486 | WP_000213700.1 | antirestriction protein | - |
| NMK59_RS23090 (4590688) | 4590688..4590822 | + | 135 | Protein_4518 | hypothetical protein | - |
| NMK59_RS23100 (4592081) | 4592081..4592425 | + | 345 | Protein_4520 | DNA repair protein RadC | - |
| NMK59_RS23105 (4592494) | 4592494..4592715 | + | 222 | WP_001220316.1 | DUF987 domain-containing protein | - |
| NMK59_RS23110 (4592790) | 4592790..4593164 | + | 375 | WP_000017094.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
| NMK59_RS23115 (4593211) | 4593211..4593588 | + | 378 | WP_000854698.1 | TA system toxin CbtA family protein | Toxin |
| NMK59_RS23120 (4593585) | 4593585..4594073 | + | 489 | WP_001054226.1 | DUF5983 family protein | - |
| NMK59_RS23125 (4594085) | 4594085..4594282 | + | 198 | WP_000839251.1 | DUF957 domain-containing protein | - |
| NMK59_RS23130 (4594367) | 4594367..4595209 | + | 843 | WP_001280439.1 | DUF4942 domain-containing protein | - |
| NMK59_RS23140 (4597389) | 4597389..4597667 | - | 279 | WP_012816821.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 4578063..4596745 | 18682 | |
| - | inside | IScluster/Tn | - | - | 4590832..4596745 | 5913 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 126 a.a. Molecular weight: 13975.94 Da Isoelectric Point: 7.9087
>T251849 WP_000854698.1 NZ_CP101302:4593211-4593588 [Escherichia coli]
MKTLPDTHVREASGCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGAPSQLINSIDILRARRATGLMTRSHYRTVNDITLGKRTEAKR
MKTLPDTHVREASGCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGAPSQLINSIDILRARRATGLMTRSHYRTVNDITLGKRTEAKR
Download Length: 378 bp
Antitoxin
Download Length: 125 a.a. Molecular weight: 13732.42 Da Isoelectric Point: 5.4488
>AT251849 WP_000017094.1 NZ_CP101302:4592790-4593164 [Escherichia coli]
VSGTLHETNYPNDNNDRPWWGLPCTVTPCFGARLVQEGNQLHYLADRAGIRGQFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYARGLTCEADTLGSCGYVYMAVYPTLAPATTS
VSGTLHETNYPNDNNDRPWWGLPCTVTPCFGARLVQEGNQLHYLADRAGIRGQFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYARGLTCEADTLGSCGYVYMAVYPTLAPATTS
Download Length: 375 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0F3UPG9 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0F3T7G0 |