Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 3957163..3957788 Replicon chromosome
Accession NZ_CP101302
Organism Escherichia coli strain 2000-3039

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag NMK59_RS19980 Protein ID WP_000911330.1
Coordinates 3957163..3957561 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID U9XQV3
Locus tag NMK59_RS19985 Protein ID WP_000450524.1
Coordinates 3957561..3957788 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NMK59_RS19960 (3953041) 3953041..3953241 + 201 WP_000383836.1 YpfN family protein -
NMK59_RS19965 (3953351) 3953351..3954049 - 699 WP_000679812.1 esterase -
NMK59_RS19970 (3954123) 3954123..3956138 - 2016 WP_000829332.1 tRNA cytosine(34) acetyltransferase TmcA -
NMK59_RS19975 (3956153) 3956153..3957016 - 864 WP_001267508.1 neutral zinc metallopeptidase -
NMK59_RS19980 (3957163) 3957163..3957561 - 399 WP_000911330.1 type II toxin-antitoxin system VapC family toxin Toxin
NMK59_RS19985 (3957561) 3957561..3957788 - 228 WP_000450524.1 toxin-antitoxin system antitoxin VapB Antitoxin
NMK59_RS19990 (3957942) 3957942..3958655 - 714 WP_001295467.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
NMK59_RS19995 (3958868) 3958868..3959902 - 1035 WP_001297320.1 outer membrane protein assembly factor BamC -
NMK59_RS20000 (3959919) 3959919..3960797 - 879 WP_001295469.1 4-hydroxy-tetrahydrodipicolinate synthase -
NMK59_RS20005 (3960943) 3960943..3961515 + 573 WP_000176187.1 glycine cleavage system transcriptional repressor -
NMK59_RS20010 (3961515) 3961515..3961985 + 471 WP_001068682.1 thioredoxin-dependent thiol peroxidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14894.25 Da        Isoelectric Point: 9.2216

>T251846 WP_000911330.1 NZ_CP101302:c3957561-3957163 [Escherichia coli]
MLKFMLDTNICIFTIKNKPVHVRERFNLNSGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRLVVLDYDSAAATHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIVVTNNTREFERVAGIRLEDWS

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8498.61 Da        Isoelectric Point: 4.3867

>AT251846 WP_000450524.1 NZ_CP101302:c3957788-3957561 [Escherichia coli]
METTVFLSNRSQAVRLPKAVALPEDVKKVEIIAIGRTRIITPAGESWDSWFDGENVSADFMDIRDQPAMQERESF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A829CM33

References