Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1347200..1347818 Replicon chromosome
Accession NZ_CP101302
Organism Escherichia coli strain 2000-3039

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag NMK59_RS06345 Protein ID WP_001291435.1
Coordinates 1347200..1347418 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag NMK59_RS06350 Protein ID WP_000344800.1
Coordinates 1347444..1347818 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NMK59_RS06310 (1342489) 1342489..1343061 + 573 WP_000779826.1 YbaY family lipoprotein -
NMK59_RS06315 (1343092) 1343092..1343403 - 312 WP_000409911.1 MGMT family protein -
NMK59_RS06325 (1343782) 1343782..1344135 + 354 WP_000878141.1 DUF1428 family protein -
NMK59_RS06330 (1344177) 1344177..1345727 - 1551 WP_001299455.1 cyclic-guanylate-specific phosphodiesterase PdeB -
NMK59_RS06335 (1345891) 1345891..1346361 - 471 WP_000136192.1 YlaC family protein -
NMK59_RS06340 (1346477) 1346477..1347028 - 552 WP_000102564.1 maltose O-acetyltransferase -
NMK59_RS06345 (1347200) 1347200..1347418 - 219 WP_001291435.1 HHA domain-containing protein Toxin
NMK59_RS06350 (1347444) 1347444..1347818 - 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
NMK59_RS06355 (1348364) 1348364..1351513 - 3150 WP_001132469.1 efflux RND transporter permease AcrB -
NMK59_RS06360 (1351536) 1351536..1352729 - 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T251830 WP_001291435.1 NZ_CP101302:c1347418-1347200 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT251830 WP_000344800.1 NZ_CP101302:c1347818-1347444 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References