Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 622483..623078 Replicon chromosome
Accession NZ_CP101302
Organism Escherichia coli strain 2000-3039

Toxin (Protein)


Gene name chpB Uniprot ID U9Y4M4
Locus tag NMK59_RS02895 Protein ID WP_000239579.1
Coordinates 622728..623078 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID U9Y2K1
Locus tag NMK59_RS02890 Protein ID WP_001223208.1
Coordinates 622483..622734 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NMK59_RS02880 (618147) 618147..621926 + 3780 WP_000060938.1 autotransporter assembly complex protein TamB -
NMK59_RS02885 (621929) 621929..622270 + 342 WP_001219160.1 gamma-glutamylcyclotransferase -
NMK59_RS02890 (622483) 622483..622734 + 252 WP_001223208.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
NMK59_RS02895 (622728) 622728..623078 + 351 WP_000239579.1 endoribonuclease toxin ChpB Toxin
NMK59_RS02900 (623158) 623158..623688 - 531 WP_000055072.1 inorganic diphosphatase -
NMK59_RS02905 (623998) 623998..624954 + 957 WP_000265933.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
NMK59_RS02910 (625094) 625094..626596 + 1503 WP_000205800.1 sugar ABC transporter ATP-binding protein -
NMK59_RS02915 (626610) 626610..627632 + 1023 WP_001298926.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12511.45 Da        Isoelectric Point: 5.6219

>T251826 WP_000239579.1 NZ_CP101302:622728-623078 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9271.58 Da        Isoelectric Point: 4.4201

>AT251826 WP_001223208.1 NZ_CP101302:622483-622734 [Escherichia coli]
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y8A8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LQ26

References