251820

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4880035..4880689 Replicon chromosome
Accession NZ_CP101292
Organism Escherichia coli strain 2003-3014

Toxin (Protein)


Gene name cptA Uniprot ID S1EEB2
Locus tag NMK58_RS25260 Protein ID WP_000244777.1
Coordinates 4880035..4880442 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID -
Locus tag NMK58_RS25265 Protein ID WP_000354043.1
Coordinates 4880423..4880689 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NMK58_RS25240 (4875992) 4875992..4877725 - 1734 WP_000813220.1 single-stranded-DNA-specific exonuclease RecJ -
NMK58_RS25245 (4877731) 4877731..4878441 - 711 WP_000715214.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
NMK58_RS25250 (4878466) 4878466..4879362 - 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
NMK58_RS25255 (4879474) 4879474..4879995 + 522 WP_001055874.1 flavodoxin FldB -
NMK58_RS25260 (4880035) 4880035..4880442 - 408 WP_000244777.1 protein YgfX Toxin
NMK58_RS25265 (4880423) 4880423..4880689 - 267 WP_000354043.1 FAD assembly factor SdhE Antitoxin
NMK58_RS25270 (4880932) 4880932..4881912 + 981 WP_000886095.1 tRNA-modifying protein YgfZ -
NMK58_RS25275 (4882108) 4882108..4882767 - 660 WP_000250274.1 hemolysin III family protein -
NMK58_RS25280 (4882931) 4882931..4883242 - 312 WP_001182954.1 N(4)-acetylcytidine aminohydrolase -
NMK58_RS25285 (4883287) 4883287..4884720 + 1434 WP_001341859.1 6-phospho-beta-glucosidase BglA -
NMK58_RS25290 (4884777) 4884777..4885520 - 744 WP_000951964.1 SDR family oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16031.96 Da        Isoelectric Point: 11.5202

>T251820 WP_000244777.1 NZ_CP101292:c4880442-4880035 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10563.16 Da        Isoelectric Point: 5.1599

>AT251820 WP_000354043.1 NZ_CP101292:c4880689-4880423 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDLDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LFV7

Antitoxin

Source ID Structure

References