251817

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 4323826..4324451 Replicon chromosome
Accession NZ_CP101292
Organism Escherichia coli strain 2003-3014

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag NMK58_RS22405 Protein ID WP_000911330.1
Coordinates 4323826..4324224 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID U9XQV3
Locus tag NMK58_RS22410 Protein ID WP_000450524.1
Coordinates 4324224..4324451 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NMK58_RS22385 (4319704) 4319704..4319904 + 201 WP_000383836.1 YpfN family protein -
NMK58_RS22390 (4320014) 4320014..4320712 - 699 WP_000679812.1 esterase -
NMK58_RS22395 (4320786) 4320786..4322801 - 2016 WP_000829332.1 tRNA cytosine(34) acetyltransferase TmcA -
NMK58_RS22400 (4322816) 4322816..4323679 - 864 WP_001267508.1 neutral zinc metallopeptidase -
NMK58_RS22405 (4323826) 4323826..4324224 - 399 WP_000911330.1 type II toxin-antitoxin system VapC family toxin Toxin
NMK58_RS22410 (4324224) 4324224..4324451 - 228 WP_000450524.1 toxin-antitoxin system antitoxin VapB Antitoxin
NMK58_RS22415 (4324605) 4324605..4325318 - 714 WP_001295467.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
NMK58_RS22420 (4325531) 4325531..4326565 - 1035 WP_001297320.1 outer membrane protein assembly factor BamC -
NMK58_RS22425 (4326582) 4326582..4327460 - 879 WP_001311023.1 4-hydroxy-tetrahydrodipicolinate synthase -
NMK58_RS22430 (4327606) 4327606..4328178 + 573 WP_000176187.1 glycine cleavage system transcriptional repressor -
NMK58_RS22435 (4328178) 4328178..4328648 + 471 WP_001068682.1 thioredoxin-dependent thiol peroxidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14894.25 Da        Isoelectric Point: 9.2216

>T251817 WP_000911330.1 NZ_CP101292:c4324224-4323826 [Escherichia coli]
MLKFMLDTNICIFTIKNKPVHVRERFNLNSGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRLVVLDYDSAAATHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIVVTNNTREFERVAGIRLEDWS

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8498.61 Da        Isoelectric Point: 4.3867

>AT251817 WP_000450524.1 NZ_CP101292:c4324451-4324224 [Escherichia coli]
METTVFLSNRSQAVRLPKAVALPEDVKKVEIIAIGRTRIITPAGESWDSWFDGENVSADFMDIRDQPAMQERESF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A829CM33

References