Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 3428808..3429279 Replicon chromosome
Accession NZ_CP101292
Organism Escherichia coli strain 2003-3014

Toxin (Protein)


Gene name parE_1 Uniprot ID A0A0D7C2L1
Locus tag NMK58_RS17870 Protein ID WP_001303511.1
Coordinates 3429001..3429279 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID Q8XAD5
Locus tag NMK58_RS17865 Protein ID WP_001302048.1
Coordinates 3428808..3428999 (+) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NMK58_RS17815 (3423886) 3423886..3424104 - 219 WP_000683609.1 DUF4014 family protein -
NMK58_RS17820 (3424232) 3424232..3424543 - 312 WP_001289673.1 hypothetical protein -
NMK58_RS17825 (3424536) 3424536..3424763 - 228 WP_000699809.1 hypothetical protein -
NMK58_RS17830 (3424760) 3424760..3425041 - 282 WP_000603384.1 DNA-binding protein -
NMK58_RS17835 (3425074) 3425074..3425835 - 762 WP_000450872.1 DUF1627 domain-containing protein -
NMK58_RS17840 (3425861) 3425861..3426602 - 742 Protein_3491 ATP-binding protein -
NMK58_RS17845 (3426609) 3426609..3427571 - 963 WP_001444941.1 helix-turn-helix domain-containing protein -
NMK58_RS17850 (3427594) 3427594..3428019 - 426 WP_000693943.1 toxin YdaT family protein -
NMK58_RS17855 (3428016) 3428016..3428318 - 303 WP_000172738.1 transcriptional regulator -
NMK58_RS17860 (3428416) 3428416..3428787 + 372 WP_001169687.1 hypothetical protein -
NMK58_RS17865 (3428808) 3428808..3428999 + 192 WP_001302048.1 hypothetical protein Antitoxin
NMK58_RS17870 (3429001) 3429001..3429279 + 279 WP_001303511.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NMK58_RS17875 (3429566) 3429566..3429718 + 153 WP_001427316.1 DUF1391 family protein -
NMK58_RS17880 (3430139) 3430139..3430360 + 222 WP_000560218.1 killing protein KilR -
NMK58_RS17885 (3430360) 3430360..3430530 + 171 WP_001427414.1 YdaE family protein -
NMK58_RS17890 (3430604) 3430604..3430879 + 276 WP_001307773.1 hypothetical protein -
NMK58_RS17895 (3430978) 3430978..3433629 + 2652 WP_000105101.1 exodeoxyribonuclease VIII -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - nleG7' 3380114..3442160 62046


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10661.25 Da        Isoelectric Point: 5.5647

>T251810 WP_001303511.1 NZ_CP101292:3429001-3429279 [Escherichia coli]
MLPVLWLESADTDLDDITSYIARFDIDAAERLWQRLRGCVLPLSEHPYLYPPSDRVPGLREIVAHPNYIILYRVTTSSVE
VVNVIHARRQFP

Download         Length: 279 bp

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7463.47 Da        Isoelectric Point: 8.6828

>AT251810 WP_001302048.1 NZ_CP101292:3428808-3428999 [Escherichia coli]
MNRALSPMVSEFETIEQENSYNEWLRAKVATSLADPRPAIPHDEVERRMAERFAKMRKERSKQ

Download         Length: 192 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 5CZF
PDB 5CW7
PDB 5CZE

Antitoxin

Source ID Structure
PDB 5CZF
PDB 3ZBE
PDB 5CW7
AlphaFold DB A0A829CTP0

References