251809

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 3109395..3109921 Replicon chromosome
Accession NZ_CP101292
Organism Escherichia coli strain 2003-3014

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag NMK58_RS16185 Protein ID WP_000323025.1
Coordinates 3109395..3109682 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag NMK58_RS16190 Protein ID WP_000534858.1
Coordinates 3109682..3109921 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NMK58_RS16135 (3104419) 3104419..3104634 - 216 WP_000839590.1 phage lysis protein EssD -
NMK58_RS16140 (3104854) 3104854..3105024 + 171 WP_001405948.1 putative zinc-binding protein YnfU -
NMK58_RS16145 (3105388) 3105388..3105603 - 216 WP_000066483.1 cold shock-like protein CspB -
NMK58_RS16150 (3105904) 3105904..3106116 + 213 WP_000087756.1 cold shock-like protein CspF -
NMK58_RS16155 (3106171) 3106171..3106260 + 90 WP_120795389.1 hypothetical protein -
NMK58_RS16160 (3106538) 3106538..3107290 - 753 WP_001047133.1 antitermination protein -
NMK58_RS16165 (3107304) 3107304..3108353 - 1050 WP_001265198.1 DUF968 domain-containing protein -
NMK58_RS16170 (3108355) 3108355..3108633 - 279 WP_012304870.1 hypothetical protein -
NMK58_RS16175 (3108700) 3108700..3108951 - 252 WP_000980994.1 protein Rem -
NMK58_RS16180 (3109168) 3109168..3109323 - 156 WP_000813254.1 type I toxin-antitoxin system toxin HokD -
NMK58_RS16185 (3109395) 3109395..3109682 - 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
NMK58_RS16190 (3109682) 3109682..3109921 - 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
NMK58_RS16195 (3109946) 3109946..3110251 + 306 WP_001326990.1 protein YdfV -
NMK58_RS16200 (3110454) 3110454..3110786 + 333 WP_001317460.1 FlxA-like family protein -
NMK58_RS16205 (3111223) 3111223..3111372 - 150 WP_180302674.1 protein YdfW -
NMK58_RS16210 (3111493) 3111493..3112542 - 1050 Protein_3168 ISNCY family transposase -
NMK58_RS16215 (3112597) 3112597..3113016 - 420 WP_001151195.1 DUF977 family protein -
NMK58_RS16220 (3113057) 3113057..3114022 - 966 WP_000054507.1 hypothetical protein -
NMK58_RS16225 (3114003) 3114003..3114524 - 522 WP_000705349.1 toxin YdaT family protein -
NMK58_RS16230 (3114508) 3114508..3114735 - 228 WP_000476993.1 Cro/CI family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - nleG7' / nleD 3018967..3127955 108988


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T251809 WP_000323025.1 NZ_CP101292:c3109682-3109395 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT251809 WP_000534858.1 NZ_CP101292:c3109921-3109682 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
AlphaFold DB A0A4V1CTS8

References