Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2881634..2882272 Replicon chromosome
Accession NZ_CP101292
Organism Escherichia coli strain 2003-3014

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag NMK58_RS14965 Protein ID WP_000813794.1
Coordinates 2881634..2881810 (+) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag NMK58_RS14970 Protein ID WP_001270286.1
Coordinates 2881856..2882272 (+) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NMK58_RS14945 (2877253) 2877253..2878428 - 1176 WP_024017328.1 BenE family transporter YdcO -
NMK58_RS14950 (2878520) 2878520..2879056 + 537 WP_000429155.1 DNA-binding transcriptional regulator SutR -
NMK58_RS14955 (2879129) 2879129..2881090 + 1962 WP_001341357.1 23S rRNA 5-hydroxycytidine C2501 synthase -
NMK58_RS14960 (2881182) 2881182..2881412 - 231 WP_000494244.1 YncJ family protein -
NMK58_RS14965 (2881634) 2881634..2881810 + 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
NMK58_RS14970 (2881856) 2881856..2882272 + 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
NMK58_RS14975 (2882351) 2882351..2883756 + 1406 Protein_2924 PLP-dependent aminotransferase family protein -
NMK58_RS14980 (2884001) 2884001..2885146 + 1146 WP_000047456.1 ABC transporter substrate-binding protein -
NMK58_RS14985 (2885164) 2885164..2886177 + 1014 WP_000220396.1 ABC transporter ATP-binding protein -
NMK58_RS14990 (2886178) 2886178..2887119 + 942 WP_001251332.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 2876065..2877213 1148


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T251807 WP_000813794.1 NZ_CP101292:2881634-2881810 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT251807 WP_001270286.1 NZ_CP101292:2881856-2882272 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References