Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1305488..1306106 Replicon chromosome
Accession NZ_CP101292
Organism Escherichia coli strain 2003-3014

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag NMK58_RS06240 Protein ID WP_001291435.1
Coordinates 1305488..1305706 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag NMK58_RS06245 Protein ID WP_000344800.1
Coordinates 1305732..1306106 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NMK58_RS06205 (1300778) 1300778..1301350 + 573 WP_000779826.1 YbaY family lipoprotein -
NMK58_RS06210 (1301381) 1301381..1301692 - 312 WP_000409911.1 MGMT family protein -
NMK58_RS06220 (1302070) 1302070..1302423 + 354 WP_000878140.1 DUF1428 domain-containing protein -
NMK58_RS06225 (1302465) 1302465..1304015 - 1551 WP_001342068.1 cyclic-guanylate-specific phosphodiesterase PdeB -
NMK58_RS06230 (1304179) 1304179..1304649 - 471 WP_000136192.1 YlaC family protein -
NMK58_RS06235 (1304765) 1304765..1305316 - 552 WP_000102564.1 maltose O-acetyltransferase -
NMK58_RS06240 (1305488) 1305488..1305706 - 219 WP_001291435.1 HHA domain-containing protein Toxin
NMK58_RS06245 (1305732) 1305732..1306106 - 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
NMK58_RS06250 (1306652) 1306652..1309801 - 3150 WP_001132475.1 efflux RND transporter permease AcrB -
NMK58_RS06255 (1309824) 1309824..1311017 - 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T251801 WP_001291435.1 NZ_CP101292:c1305706-1305488 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT251801 WP_000344800.1 NZ_CP101292:c1306106-1305732 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References