251797

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 671410..672242 Replicon chromosome
Accession NZ_CP101292
Organism Escherichia coli strain 2003-3014

Toxin (Protein)


Gene name yeeV Uniprot ID S1PD64
Locus tag NMK58_RS03210 Protein ID WP_000854753.1
Coordinates 671868..672242 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID V0ULY5
Locus tag NMK58_RS03205 Protein ID WP_001315620.1
Coordinates 671410..671778 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NMK58_RS03175 (668246) 668246..668701 + 456 WP_000581504.1 IrmA family protein -
NMK58_RS03180 (668780) 668780..669013 + 234 WP_001119729.1 DUF905 family protein -
NMK58_RS03185 (669113) 669113..669931 + 819 WP_001234622.1 DUF932 domain-containing protein -
NMK58_RS03190 (669986) 669986..670471 + 486 WP_000849588.1 antirestriction protein -
NMK58_RS03195 (670487) 670487..670963 + 477 WP_001186774.1 RadC family protein -
NMK58_RS03200 (671026) 671026..671247 + 222 WP_000692345.1 DUF987 domain-containing protein -
NMK58_RS03205 (671410) 671410..671778 + 369 WP_001315620.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
NMK58_RS03210 (671868) 671868..672242 + 375 WP_000854753.1 TA system toxin CbtA family protein Toxin
NMK58_RS03215 (672239) 672239..672727 + 489 WP_000777547.1 DUF5983 family protein -
NMK58_RS03220 (672739) 672739..672936 + 198 WP_000839281.1 DUF957 domain-containing protein -
NMK58_RS03225 (673021) 673021..673170 + 150 Protein_624 restriction endonuclease subunit M -
NMK58_RS03230 (673938) 673938..674081 - 144 Protein_625 HNH endonuclease -
NMK58_RS03235 (674218) 674218..674868 + 651 WP_001037966.1 HNH endonuclease -
NMK58_RS03240 (674876) 674876..675856 - 981 WP_000991415.1 sialate O-acetylesterase -
NMK58_RS03245 (675921) 675921..677027 - 1107 WP_001341302.1 N-acetylneuraminate epimerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 14005.00 Da        Isoelectric Point: 8.2905

>T251797 WP_000854753.1 NZ_CP101292:671868-672242 [Escherichia coli]
MKTLPDTHVREASSCPSPVTIWQTLLSRLLGQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEKR

Download         Length: 375 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13474.20 Da        Isoelectric Point: 6.2050

>AT251797 WP_001315620.1 NZ_CP101292:671410-671778 [Escherichia coli]
VSDTLSGTTHPDDNDDHPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLGSGGYVYLAVYPTPETKK

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LVU0

Antitoxin

Source ID Structure
AlphaFold DB V0ULY5

References