251795

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type V Classification (family/domain) ghoTS/ghoT-GhoS
Location 412401..412898 Replicon chromosome
Accession NZ_CP101292
Organism Escherichia coli strain 2003-3014

Toxin (Protein)


Gene name ghoT Uniprot ID L4JJG6
Locus tag NMK58_RS01890 Protein ID WP_001173343.1
Coordinates 412725..412898 (+) Length 58 a.a.

Antitoxin (Protein)


Gene name ghoS Uniprot ID L4JK92
Locus tag NMK58_RS01885 Protein ID WP_000398619.1
Coordinates 412401..412697 (+) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NMK58_RS01865 (409132) 409132..409851 - 720 WP_000611288.1 two-component system response regulator DcuR -
NMK58_RS01870 (409848) 409848..411479 - 1632 WP_001216487.1 sensor histidine kinase -
NMK58_RS01875 (411660) 411660..411890 + 231 WP_000371700.1 4Fe-4S mono-cluster protein YjdI -
NMK58_RS01880 (411902) 411902..412174 + 273 WP_000405647.1 GNAT family N-acetyltransferase -
NMK58_RS01885 (412401) 412401..412697 + 297 WP_000398619.1 type V toxin-antitoxin system endoribonuclease antitoxin GhoS Antitoxin
NMK58_RS01890 (412725) 412725..412898 + 174 WP_001173343.1 type V toxin-antitoxin system toxin GhoT Toxin
NMK58_RS01895 (413017) 413017..414534 - 1518 WP_001295074.1 lysine--tRNA ligase -
NMK58_RS01900 (414771) 414771..416228 - 1458 WP_000856834.1 dipeptide/tripeptide permease DtpC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin GhoT/OrtT

(4-57)

Antitoxin

Endoribonuclease antitoxin GhoS

(5-94)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6555.06 Da        Isoelectric Point: 10.2288

>T251795 WP_001173343.1 NZ_CP101292:412725-412898 [Escherichia coli]
MALFSKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF

Download         Length: 174 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11467.97 Da        Isoelectric Point: 4.1705

>AT251795 WP_000398619.1 NZ_CP101292:412401-412697 [Escherichia coli]
MEGKNKFNTYVVSFDYPSSYSSVFLRLRSLMYDMNFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDI
DFDLNIMTVDDYFRQFYK

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9QI41

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBH6

References