251786

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 142400..143043 Replicon plasmid pEC21Z014-165K
Accession NZ_CP101275
Organism Escherichia coli strain EC21Z-014

Toxin (Protein)


Gene name vagD Uniprot ID V0UN72
Locus tag NML17_RS24610 Protein ID WP_001034044.1
Coordinates 142627..143043 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID B1P7N7
Locus tag NML17_RS24605 Protein ID WP_001261286.1
Coordinates 142400..142630 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NML17_RS24590 (137537) 137537..137767 + 231 WP_001261278.1 type II toxin-antitoxin system VapB family antitoxin -
NML17_RS24595 (137764) 137764..138180 + 417 WP_001034046.1 type II toxin-antitoxin system VapC family toxin -
NML17_RS24600 (138225) 138225..142019 - 3795 WP_001144732.1 hypothetical protein -
NML17_RS24605 (142400) 142400..142630 + 231 WP_001261286.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
NML17_RS24610 (142627) 142627..143043 + 417 WP_001034044.1 type II toxin-antitoxin system VapC family toxin Toxin
NML17_RS24615 (143118) 143118..144683 + 1566 WP_001128474.1 AAA family ATPase -
NML17_RS24620 (144668) 144668..145690 + 1023 WP_032174242.1 helicase UvrD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid sitABCD iutA / iucD / iucC / iucB / iucA 1..164754 164754


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-129)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15232.66 Da        Isoelectric Point: 6.8536

>T251786 WP_001034044.1 NZ_CP101275:142627-143043 [Escherichia coli]
VNKIYMLDTNICSFIMREQPEALLKHLEQSVLRGHRIVVSAITYSEMRFGATGPKASPRHVQLVDAFCERLDAVLPWDRA
AVDATTEIKVALRLAGTPIGPNDTAIAGHAIAACAILVTNNVREFERVPGLVLEDWVR

Download         Length: 417 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8747.86 Da        Isoelectric Point: 4.3775

>AT251786 WP_001261286.1 NZ_CP101275:142400-142630 [Escherichia coli]
MRTVSIFKNGNNRAIRLPRDLDFEGVSELEIVREGDSIILRPVRPTWGSFLELEKADPDFMTEREDVVSDEGRVNL

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CHW1

Antitoxin

Source ID Structure
AlphaFold DB A0A829CKZ6

References