251776

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 4372564..4373150 Replicon chromosome
Accession NZ_CP101274
Organism Escherichia coli strain EC21Z-014

Toxin (Protein)


Gene name hicA Uniprot ID A0A0H0RQZ4
Locus tag NML17_RS21420 Protein ID WP_042014162.1
Coordinates 4372920..4373150 (-) Length 77 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID U9Y7E1
Locus tag NML17_RS21415 Protein ID WP_000593555.1
Coordinates 4372564..4372923 (-) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NML17_RS21390 (4368696) 4368696..4369640 + 945 WP_000947068.1 nickel ABC transporter permease subunit NikB -
NML17_RS21395 (4369637) 4369637..4370470 + 834 WP_208464810.1 nickel ABC transporter permease subunit NikC -
NML17_RS21400 (4370470) 4370470..4371234 + 765 WP_001136236.1 nickel import ATP-binding protein NikD -
NML17_RS21405 (4371231) 4371231..4372037 + 807 WP_000173666.1 nickel import ATP-binding protein NikE -
NML17_RS21410 (4372043) 4372043..4372444 + 402 WP_001190062.1 nickel-responsive transcriptional regulator NikR -
NML17_RS21415 (4372564) 4372564..4372923 - 360 WP_000593555.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
NML17_RS21420 (4372920) 4372920..4373150 - 231 WP_042014162.1 type II toxin-antitoxin system HicA family toxin Toxin
NML17_RS21425 (4373254) 4373254..4374378 - 1125 WP_001314210.1 ABC transporter permease -
NML17_RS21430 (4374378) 4374378..4377113 - 2736 WP_000149165.1 ribosome-associated ATPase/putative transporter RbbA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(15-65)

Antitoxin

Uncharacterised protein family HicB

(60-112)


Sequences

Toxin        


Download         Length: 77 a.a.        Molecular weight: 8419.79 Da        Isoelectric Point: 8.5518

>T251776 WP_042014162.1 NZ_CP101274:c4373150-4372920 [Escherichia coli]
MDQLFKSPLPQGIKWTDIESLVKALGGEIKEGRGSRCKFILNMSVACFHRPHPSPDTDKGAVESVRDWLLSIGVKP

Download         Length: 231 bp

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13402.27 Da        Isoelectric Point: 5.1987

>AT251776 WP_000593555.1 NZ_CP101274:c4372923-4372564 [Escherichia coli]
MIKLKTPNSMEIAGQPAVITYVPELNAFRGKFLGLSGYCDFVSDSIQGLQKEGELSLREYLEDCKAAGIEPYARTEKIKT
FTLRYPESLSERLNNAAAQQQVSVNTYIIETLNERLNHL

Download         Length: 360 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H0RQZ4

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LKZ6

References